Nanomaterials in the Context of Type 2 Immune Responses-Fears and Potentials

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2017 May 11

PMID 28487697

Citations 10

Authors

Martin Himly

Robert Mills-Goodlet

Mark Geppert

Albert Duschl

Affiliations

Soon will be listed here.

Abstract

The type 2 immune response is an adaptive immune program involved in defense against parasites, detoxification, and wound healing, but is predominantly known for its pathophysiological effects, manifesting as allergic disease. Engineered nanoparticles (NPs) are non-self entities that, to our knowledge, do not stimulate detrimental type 2 responses directly, but have the potential to modulate ongoing reactions in various ways, including the delivery of substances aiming at providing a therapeutic benefit. We review, here, the state of knowledge concerning the interaction of NPs with type 2 immune responses and highlight their potential as a multifunctional platform for therapeutic intervention.

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