Changes in Human Hepatic Metabolism in Steatosis and Cirrhosis

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2017 May 11

PMID 28487605

Citations 19

Authors

Zoe Schofield

Michelle Ac Reed

Philip N Newsome

David H Adams

Ulrich L Gunther

Patricia F Lalor

Affiliations

Soon will be listed here.

Abstract

Aim: To understand the underlying metabolic changes in human liver disease we have applied nuclear magnetic resonance (NMR) metabolomics analysis to human liver tissue.

Methods: We have carried out pilot study using H-NMR to derive metabolomic signatures from human liver from patients with steatosis, nonalcoholic steatohepatitis (NASH) or alcohol-related liver damage (ARLD) to identify species that can predict outcome and discriminate between alcohol and metabolic-induced liver injuries.

Results: Changes in branched chain amino acid homeostasis, tricarboxylic acid cycle and purine biosynthesis intermediates along with betaine were associated with the development of cirrhosis in both ARLD and nonalcoholic fatty liver disease. Species such as propylene glycol and as yet unidentified moieties that allowed discrimination between NASH and ARLD samples were also detected using our approach.

Conclusion: Our high throughput, non-destructive technique for multiple analyte quantification in human liver specimens has potential for identification of biomarkers with prognostic and diagnostic significance.

Citing Articles

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Comprehensive analysis of epigenetic and epitranscriptomic genes' expression in human NAFLD.

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Difference and clinical value of metabolites in plasma and feces of patients with alcohol-related liver cirrhosis.

Xu Y, Hao Y, Ma L, Zhang M, Niu X, Li Y World J Gastroenterol. 2023; 29(22):3534-3547.

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Akkermansia muciniphila alleviates high-fat-diet-related metabolic-associated fatty liver disease by modulating gut microbiota and bile acids.

Wu W, Kaicen W, Bian X, Yang L, Ding S, Li Y Microb Biotechnol. 2023; 16(10):1924-1939.

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Tracer-Based Metabolic Analysis by NMR in Intact Perfused Human Liver Tissue.

Saborano R, Shepherd E, Gunther U, Lalor P Methods Mol Biol. 2023; 2675:167-180.

PMID: 37258763 DOI: 10.1007/978-1-0716-3247-5_13.

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