Dissociation of Digoxin-like Immunoreactivity and Na+,K+-ATPase Inhibitory Activity in Rat Plasma

Overview

Journal Experientia

Specialty Science

Date 1988 Dec 1

PMID 2848712

Citations 2

Authors

K Yamada

A Goto

M Ishii

M Yoshioka

T Sugimoto

Affiliations

Soon will be listed here.

Abstract

We measured endogenous digitalis-like factor (EDF) in rat plasma during acute saline infusion by two different procedures. Na+,K+-ATPase inhibitory activity in the rat plasma significantly increased during saline loading (7.8 +/- 2.2 vs 2.5 +/- 0.9%, with and without acute saline loading, respectively, p less than 0.05). On the other hand, the plasma digoxin-like immunoreactivity significantly decreased during acute saline loading (16.9 +/- 1.6 vs 32.0 +/- 2.8 pg digoxin equivalents/ml, with and without acute saline loading, respectively, p less than 0.01). These results indicate that the major substances detected by digoxin-like immunoreactivity and direct Na+,K+-ATPase inhibitory activity are completely different, at least in rat plasma.

Citing Articles

Further evidence for the dissociation of digoxin-like immunoreactivity from Na+,K(+)-ATPase inhibitory activity.

Yamada K, Goto A, Ishii M, Yoshioka M, Sugimoto T Experientia. 1990; 46(10):1041-3.

PMID: 2171976 DOI: 10.1007/BF01940667.

In search of synaptosomal Na+,K(+)-ATPase regulators.

Rodriguez de Lores Arnaiz G Mol Neurobiol. 1992; 6(4):359-75.

PMID: 1363048 DOI: 10.1007/BF02757941.

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