Diagnostic and Treatment Modalities for Patients with Cervical Lymph Node Metastases of Unknown Primary Site - Current Status and Challenges

Overview

Journal Radiat Oncol

Publisher Biomed Central

Specialties Oncology
Radiology

Date 2017 May 11

PMID 28486947

Citations 19

Authors

Jens Muller von der Grun

Aykut Tahtali

Shahram Ghanaati

Claus Rodel

Panagiotis Balermpas

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: This review aims to provide a comprehensive overview of the literature and elucidate open questions for future clinical trials concerning diagnostics and treatment modalities for cervical cancer of unknown primary (CUP).

Methods: A literature search for head and neck CUP was performed with focus on diagnostics and therapies as well as molecular markers.

Results: High level evidence on CUP is limited. However, it seems that a consensus exists regarding the optimal diagnostic procedures. The correct implementation of biomarkers for patient stratification and treatment remains unclear. An even greater dispute dominates about the ideal treatment with publications ranging from sole surgery to surgery with postoperative bilateral radiotherapy with inclusion of the mucosa and concomitant chemotherapy.

Conclusions: Cervical CUP represents a very heterogeneous malignant disease. On this account many aspects concerning treatment optimization remain unclear, despite a considerable number of publications in the past. Future research in form of prospective randomized trials is needed in order to better define patient stratification criteria and enable tailored treatment.

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