Diverging Concepts and Novel Perspectives in Regenerative Medicine

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2017 May 10

PMID 28486410

Citations 10

Authors

Maurizio Muraca

Martina Piccoli

Chiara Franzin

Anna Maria Tolomeo

Marcin Jurga

Michela Pozzobon

Giorgio Perilongo

Affiliations

Soon will be listed here.

Abstract

Regenerative medicine has rapidly evolved, due to progress in cell and molecular biology allowing the isolation, characterization, expansion, and engineering of cells as therapeutic tools. Despite past limited success in the clinical translation of several promising preclinical results, this novel field is now entering a phase of renewed confidence and productivity, marked by the commercialization of the first cell therapy products. Ongoing issues in the field include the use of pluripotent vs. somatic and of allogenic vs. autologous stem cells. Moreover, the recognition that several of the observed beneficial effects of cell therapy are not due to integration of the transplanted cells, but rather to paracrine signals released by the exogenous cells, is generating new therapeutic perspectives in the field. Somatic stem cells are outperforming embryonic and induced pluripotent stem cells in clinical applications, mainly because of their more favorable safety profile. Presently, both autologous and allogeneic somatic stem cells seem to be equally safe and effective under several different conditions. Recognition that a number of therapeutic effects of transplanted cells are mediated by paracrine signals, and that such signals can be found in extracellular vesicles isolated from culture media, opens novel therapeutic perspectives in the field of regenerative medicine.

Citing Articles

Stem cells or their exosomes: which is preferred in COVID-19 treatment?.

Fayazi Hosseini N, Dalirfardouei R, Aliramaei M, Najafi R Biotechnol Lett. 2022; 44(2):159-177.

PMID: 35043287 PMC: 8765836. DOI: 10.1007/s10529-021-03209-8.

The Potential Role of Extracellular Vesicles in COVID-19 Treatment: Opportunity and Challenge.

Yan Y, Zhou W, Wang Y, Guo Q, Zhao F, Zhu Z Front Mol Biosci. 2021; 8:699929.

PMID: 34368228 PMC: 8345113. DOI: 10.3389/fmolb.2021.699929.

Mesenchymal Stem Cells and COVID-19: Cure, Prevention, and Vaccination.

Afarid M, Sanie-Jahromi F Stem Cells Int. 2021; 2021:6666370.

PMID: 34035820 PMC: 8103964. DOI: 10.1155/2021/6666370.

The role of preservation in the variability of regenerative medicine products.

Yu G, Hubel A Regen Eng Transl Med. 2020; 5(4):323-331.

PMID: 33225043 PMC: 7677879. DOI: 10.1007/s40883-019-00110-9.

Holistic Approach of Swiss Fetal Progenitor Cell Banking: Optimizing Safe and Sustainable Substrates for Regenerative Medicine and Biotechnology.

Laurent A, Hirt-Burri N, Scaletta C, Michetti M, de Buys Roessingh A, Raffoul W Front Bioeng Biotechnol. 2020; 8:557758.

PMID: 33195124 PMC: 7644790. DOI: 10.3389/fbioe.2020.557758.

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