Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2017 May 10

PMID 28484308

Citations 53

Authors

Rosa Casas

Mireia Urpi-Sarda

Emilio Sacanella

Sara Arranz

Dolores Corella

Olga Castaner

Rosa-Maria Lamuela-Raventos

Jordi Salas-Salvado

Jose Lapetra

Maria P Portillo

Ramon Estruch

Affiliations

Soon will be listed here.

Abstract

To evaluate the long-term effects of a Mediterranean diet (MeDiet) intervention on the plasma concentrations of inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease. . 66 participants from primary care centers affiliated with the Hospital Clinic of Barcelona were randomized into 3 groups: MeDiet plus extra virgin olive oil (EVOO) or nuts and a low-fat diet (LFD). At baseline and at 3 and 5 years, we evaluated the changes in the plasma concentrations of 24 inflammatory biomarkers related to the different stages of the atherosclerotic process by Luminex®. At 3 and 5 years, both MeDiet groups showed a significant reduction of IL-6, IL-8, MCP-1, and MIP-1 ( < 0.05; all) compared to LFD. IL-1, IL-5, IL-7, IL-12p70, IL-18, TNF-, IFN-, GCSF, GMCSF, and ENA78 ( < 0.05; all) only decreased in the MeDiet+EVOO group and E-selectin and sVCAM-1 ( < 0.05; both) in the MeDiet+nuts group. . Long-term adherence to MeDiet decreases the plasma concentrations of inflammatory biomarkers related to different steps of atheroma plaque development in elderly persons at high cardiovascular risk.

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