Exact Firing Time Statistics of Neurons Driven by Discrete Inhibitory Noise

Overview

Journal Sci Rep

Specialty Science

Date 2017 May 10

PMID 28484244

Authors

Simona Olmi

David Angulo-Garcia

Alberto Imparato

Alessandro Torcini

Affiliations

Soon will be listed here.

Abstract

Neurons in the intact brain receive a continuous and irregular synaptic bombardment from excitatory and inhibitory pre- synaptic neurons, which determines the firing activity of the stimulated neuron. In order to investigate the influence of inhibitory stimulation on the firing time statistics, we consider Leaky Integrate-and-Fire neurons subject to inhibitory instantaneous post- synaptic potentials. In particular, we report exact results for the firing rate, the coefficient of variation and the spike train spectrum for various synaptic weight distributions. Our results are not limited to stimulations of infinitesimal amplitude, but they apply as well to finite amplitude post-synaptic potentials, thus being able to capture the effect of rare and large spikes. The developed methods are able to reproduce also the average firing properties of heterogeneous neuronal populations.

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