Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2017 May 9

PMID 28481269

Authors

Xue-Qin Hou

Lei Wang

Fu-Gang Wang

Xiao-Min Zhao

Han-Ting Zhang

Affiliations

Soon will be listed here.

Abstract

RNA interference (RNAi), including microRNAs, is an important player in the mediation of differentiation and migration of stem cells via target genes. It is used as a potential strategy for gene therapy for central nervous system (CNS) diseases. Stem cells are considered vectors of RNAi due to their capacity to deliver RNAi to other cells. In this review, we discuss the recent advances in studies of RNAi pathways in controlling neuronal differentiation and migration of stem cells. We also highlight the utilization of a combination of RNAi and stem cells in treatment of CNS diseases.

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