COGNITIVE-ENHANCING PROPERTIES OF (RUBIACEAE) AND (FABACEAE) IN SCOPOLAMINE-INDUCED AMNESIC MICE

Overview

Journal Afr J Tradit Complement Altern Med

Specialty Rehabilitation Medicine

Date 2017 May 9

PMID 28480424

Citations 2

Authors

Elufioye Taiwo O

Hameed Halimah A

Affiliations

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Abstract

Background: Cognitive disorders associated with aging have been successfully managed by African traditional medical practitioners using various plants. This study evaluated the cognitive enhancing potentials of (L) Rubiaceae and (DC) ex. K Heyne in scopolamine induced amnesic animals.

Materials And Methods: The anti-amnesic activity of the ethyl acetate extracts of and at doses of 4 mg/kg, 6 mg/kg and 8 mg/kg were assessed in scopolamine induced amnesic mice using Morris water maze test model. Effect of the extracts on the histology of the hippocampus was also evaluated.

Results: The ethyl acetate extract of and ameliorated scopolamine induced memory deficit in the animals under study. There was no effect of the extract on the histology of the hippocampus. However, there was an increase in the density of cells in the hippocampus of treated group as compared to the untreated.

Conclusion: and showed considerable enhancement of cognition in scopolamine induced amnesic mice.

Citing Articles

Potential Herb-Drug Interactions in the Management of Age-Related Cognitive Dysfunction.

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Antioxidant and Cell Proliferation Properties of the Vietnamese Traditional Medicinal Plant .

Kim S, Cuong To D, Hung Nguyen P, Nguyen Y, Cho B, Tran M Molecules. 2020; 25(20).

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