Duration and Frequency of Migraines Affect Cognitive Function: Evidence from Neuropsychological Tests and Event-related Potentials

Overview

Journal J Headache Pain

Publisher Biomed Central

Date 2017 May 7

PMID 28477306

Citations 43

Authors

Lifang Huang

Hong Juan Dong

Xi Wang

Yan Wang

Zheman Xiao

Affiliations

Soon will be listed here.

Abstract

Background: The aim of this study was to evaluate the changes in the cognitive performance of migraine patients using a comprehensive series of cognitive/behavioral and electrophysiological tests.

Method: A randomized, cross-sectional, within subject approach was used to compare neuropsychological and electrophysiological evaluations from migrane-affected and healthy subjects.

Results: Thirty-four patients with migraine (6 males, 28 females, average 36 years old) were included. Migraineurs performed worse in the majority of the Montreal Cognitive Assessment (MoCA) (p = 0.007) compared to the healthy subjects, significantly in language (p = 0.005), memory (p = 0.006), executive functions (p = 0.042), calculation (p = 0.018) and orientation (p = 0.012). Migraineurs had a lower score on the memory trial of the Rey-Osterrieth complex figure test (ROCF) (p = 0.012). The P3 latency in Fz, Cz, Pz was prolonged in migraineurs compared with the normal control group (P < 0.001). In addition, we analyzed significant correlations between MoCA score and the duration of migraine. We also observed that a decrease in the MoCA-executive functions and calculation score and in the ROCF-recall score were both correlated to the frequency of migraine. Migraineurs were more anxious than healthy subjects (p = 0.001), which is independent of cognitive testing. Differences were unrelated to age, gender and literacy.

Conclusions: Cognitive performance decreases during migraine, and cognitive dysfunction can be related to the duration and frequency of a migraine attack.

Citing Articles

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Chowdhury D, Datta D, Mundra A, Duggal A, Krishnan A Ann Indian Acad Neurol. 2024; 27(3):254-263.

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