P62/SQSTM1 Levels Predicts Radiotherapy Resistance in Hypopharyngeal Carcinomas

Overview

Journal Am J Cancer Res

Specialty Oncology

Date 2017 May 5

PMID 28469960

Citations 5

Authors

Akihito Arai

Tokuhiro Chano

Kaichiro Ikebuchi

Yusuke Hama

Yasuko Ochi

Hitosuke Tameno

Taketoshi Shimada

Affiliations

Soon will be listed here.

Abstract

Hypopharyngeal carcinoma is one of the worst prognostic malignancies among head and neck carcinomas. Therefore, a good biomarker should be identified to predict the best therapeutic option before starting the treatment. In cell models, p62/SQSTM1 levels affected the Nrf2-Keap1 pathway, ROS levels, GSH/GSSG ratios and cell growth, especially under irradiation rather than under CDDP exposure, which was toxic despite p62/SQSTM1 status. In a clinical cohort of hypopharyngeal carcinomas, high levels of p62/SQSTM1 significantly predicted poor prognosis (log-rank test, Chi-square value = 6.750, = 0.0094) and maximum critical risk (Cox proportional hazard ratio = 4.405, = 0.0086), especially in the radiotherapy group. Therefore, when p62/SQSTM1 is elevated in the biopsy section, hypopharyngeal carcinoma should be treated with surgical and/or chemotherapeutic options.

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