Cellular Mechanism of Ischemic Acute Renal Failure: Role of Ca2+ and Calcium Entry Blockers

Overview

Journal Klin Wochenschr

Specialty General Medicine

Date 1988 Sep 15

PMID 2846945

Citations 4

Authors

R W Schrier

J Hensen

Affiliations

Soon will be listed here.

Abstract

This presentation briefly reviews the cellular mechanism of ischemic acute renal failure (ARF) with particular emphasis on the role of Ca2+ and calcium entry blockers (CEB). Vascular consequences of an ischemic renal insult including vasoconstriction, diminished glomerular permeability, loss of autoregulation, and hypersensitivity to renal nerve stimulation may relate to increased cellular Ca2+ concentration in the renal afferent arteriole and glomerular mesangial cells. Evidence is also presented that the ischemic injury to tubular plasma membranes is associated with increased Ca2+ uptake. With an ischemic insult of a short duration, the renal mitochondria are able to buffer the increased cellular Ca2+. However, after an ischemic insult of long duration, the Ca2+ over-loaded mitochondria deteriorate, adenosine triphosphate (ATP) synthesis decreases, and cell death follows. If a sufficient number of renal tubular cells undergo this cell death, tubular obstruction, i.e. the maintenance phase of ARF, occurs.

Citing Articles

Acid-sensing ion channel 1a is involved in ischaemia/reperfusion induced kidney injury by increasing renal epithelia cell apoptosis.

Song N, Lu Z, Zhang J, Shi Y, Ning Y, Chen J J Cell Mol Med. 2019; 23(5):3429-3440.

PMID: 30793492 PMC: 6484315. DOI: 10.1111/jcmm.14238.

Dynamic transcriptomic analysis of Ischemic Injury in a Porcine Pre-Clinical Model mimicking Donors Deceased after Circulatory Death.

Giraud S, Steichen C, Allain G, Couturier P, Labourdette D, Lamarre S Sci Rep. 2018; 8(1):5986.

PMID: 29654283 PMC: 5899088. DOI: 10.1038/s41598-018-24282-6.

Perfusion of isolated rat kidney with Mesenchymal Stromal Cells/Extracellular Vesicles prevents ischaemic injury.

Gregorini M, Corradetti V, Pattonieri E, Rocca C, Milanesi S, Peloso A J Cell Mol Med. 2017; 21(12):3381-3393.

PMID: 28639291 PMC: 5706569. DOI: 10.1111/jcmm.13249.

Intrarenal infusion of gallopamil in acute renal failure. A preliminary report.

Lumlertgul D, Wongmekiat O, Sirivanichai C, Hundagoon P, KEOPLUNG M, Conger J Drugs. 1991; 42 Suppl 1:44-50.

PMID: 1718694 DOI: 10.2165/00003495-199100421-00009.

References

Goldfarb D, Iaina A, Serban I, Gavendo S, Kapuler S, ELIAHOU H . Beneficial effect of verapamil in ischemic acute renal failure in the rat. Proc Soc Exp Biol Med. 1983; 172(3):389-92. DOI: 10.3181/00379727-172-41576. View

BURKE T, Cronin R, Duchin K, PETERSON L, Schrier R . Ischemia and tubule obstruction during acute renal failure in dogs: mannitol in protection. Am J Physiol. 1980; 238(4):F305-14. DOI: 10.1152/ajprenal.1980.238.4.F305. View

Trump B, Berezesky I, Laiho K, Osornio A, Mergner W, Smith M . The role of calcium in cell injury. A review. Scan Electron Microsc. 1980; (Pt 2):437-62, 492. View

Chien K, Abrams J, Serroni A, Martin J, Farber J . Accelerated phospholipid degradation and associated membrane dysfunction in irreversible, ischemic liver cell injury. J Biol Chem. 1978; 253(13):4809-17. View

Donohoe J, Venkatachalam M, Bernard D, LEVINSKY N . Tubular leakage and obstruction after renal ischemia: structural-functional correlations. Kidney Int. 1978; 13(3):208-22. DOI: 10.1038/ki.1978.31. View

Cronin R, de Torrente A, Miller P, Bulger R, BURKE T, Schrier R . Pathogenic mechanisms in early norepinephrine-induced acute renal failure: functional and histological correlates of protection. Kidney Int. 1978; 14(2):115-25. DOI: 10.1038/ki.1978.99. View

ROSSI C, Lehninger A . STOICHIOMETRY OF RESPIRATORY STIMULATION, ACCUMULATION OF CA++ AND PHOSPHATE, AND OXIDATIVE PHOSPHORYLATION IN RAT LIVER MITOCHONDRIA. J Biol Chem. 1964; 239:3971-80. View

Malis C, Cheung J, Leaf A, Bonventre J . Effects of verapamil in models of ischemic acute renal failure in the rat. Am J Physiol. 1983; 245(6):F735-42. DOI: 10.1152/ajprenal.1983.245.6.F735. View

Schrier R, Arnold P, Van Putten V, BURKE T . Cellular calcium in ischemic acute renal failure: role of calcium entry blockers. Kidney Int. 1987; 32(3):313-21. DOI: 10.1038/ki.1987.211. View

10.

de Torrente A, Miller P, Cronin R, Paulsin P, Erickson A, Schrier R . Effects of furosemide and acetylcholine in norepinephrine-induced acute renal failure. Am J Physiol. 1978; 235(2):F131-6. DOI: 10.1152/ajprenal.1978.235.2.F131. View

11.

Shapiro J, Cheung C, Itabashi A, Chan L, Schrier R . The effect of verapamil on renal function after warm and cold ischemia in the isolated perfused rat kidney. Transplantation. 1985; 40(6):596-600. DOI: 10.1097/00007890-198512000-00004. View

12.

Matthys E, Patel Y, Kreisberg J, Stewart J, Venkatachalam M . Lipid alterations induced by renal ischemia: pathogenic factor in membrane damage. Kidney Int. 1984; 26(2):153-61. DOI: 10.1038/ki.1984.149. View

13.

Arnold P, Lumlertgul D, BURKE T, Schrier R . In vitro versus in vivo mitochondrial calcium loading in ischemic acute renal failure. Am J Physiol. 1985; 248(6 Pt 2):F845-50. DOI: 10.1152/ajprenal.1985.248.6.F845. View

14.

Schanne F, Kane A, Young E, Farber J . Calcium dependence of toxic cell death: a final common pathway. Science. 1979; 206(4419):700-2. DOI: 10.1126/science.386513. View

15.

Cheung J, Leaf A, Bonventre J . Mechanism of protection by verapamil and nifedipine from anoxic injury in isolated cardiac myocytes. Am J Physiol. 1984; 246(3 Pt 1):C323-9. DOI: 10.1152/ajpcell.1984.246.3.C323. View

16.

Takano T, Soltoff S, Murdaugh S, Mandel L . Intracellular respiratory dysfunction and cell injury in short-term anoxia of rabbit renal proximal tubules. J Clin Invest. 1985; 76(6):2377-84. PMC: 424382. DOI: 10.1172/JCI112250. View

17.

Nakamoto M, Shapiro J, Shanley P, Chan L, Schrier R . In vitro and in vivo protective effect of atriopeptin III on ischemic acute renal failure. J Clin Invest. 1987; 80(3):698-705. PMC: 442293. DOI: 10.1172/JCI113124. View

18.

Becker G, Fiskum G, Lehninger A . Regulation of free Ca2+ by liver mitochondria and endoplasmic reticulum. J Biol Chem. 1980; 255(19):9009-12. View

19.

Moore C . Specific inhibition of mitochondrial Ca++ transport by ruthenium red. Biochem Biophys Res Commun. 1971; 42(2):298-305. DOI: 10.1016/0006-291x(71)90102-1. View

20.

Conger J, Robinette J, Schrier R . Smooth muscle calcium and endothelium-derived relaxing factor in the abnormal vascular responses of acute renal failure. J Clin Invest. 1988; 82(2):532-7. PMC: 303544. DOI: 10.1172/JCI113628. View