Leukocyte Cell-Derived Chemotaxin-2: It's Role in Pathophysiology and Future in Clinical Medicine

Overview

Journal Clin Transl Sci

Specialties Biomedical Engineering
General Medicine

Date 2017 May 4

PMID 28466965

Citations 15

Authors

V Slowik

U Apte

Affiliations

Soon will be listed here.

Citing Articles

Hepatokines: unveiling the molecular and cellular mechanisms connecting hepatic tissue to insulin resistance and inflammation.

Miao X, Alidadipour A, Saed V, Sayyadi F, Jadidi Y, Davoudi M Acta Diabetol. 2024; 61(11):1339-1361.

PMID: 39031190 DOI: 10.1007/s00592-024-02335-9.

Global research trends and hotspots for leukocyte cell-derived chemotaxin-2 from the past to 2023: a combined bibliometric review.

Liu W, Wang Q, Yeerlan J, Yan Y, Xu L, Jia C Front Immunol. 2024; 15:1413466.

PMID: 38881894 PMC: 11176436. DOI: 10.3389/fimmu.2024.1413466.

Association between Leukocyte Cell-Derived Chemotaxin 2 and Metabolic and Renal Diseases in a Geriatric Population: A Pilot Study.

Kuzan A, Maksymowicz K, Krolewicz E, Lindner-Pawlowicz K, Zatyka P, Wojnicz P J Clin Med. 2023; 12(24).

PMID: 38137613 PMC: 10744026. DOI: 10.3390/jcm12247544.

Leukocyte cell-derived chemotaxin 2 correlates with pediatric non-alcoholic fatty liver disease.

Paine-Cabrera D, Harvey L, Robarts D, Pritchard M, Thyfault J, Weinman S Clin Transl Sci. 2023; 16(12):2719-2728.

PMID: 37877453 PMC: 10719457. DOI: 10.1111/cts.13666.

Mimicking Kidney Flow Shear Efficiently Induces Aggregation of LECT2, a Protein Involved in Renal Amyloidosis.

Ha J, Xu Y, Sekhon H, Wilkens S, Ren D, Loh S bioRxiv. 2023; .

PMID: 37503176 PMC: 10369975. DOI: 10.1101/2023.07.13.548788.

References

Ikeda D, Ageta H, Tsuchida K, Yamada H . iTRAQ-based proteomics reveals novel biomarkers of osteoarthritis. Biomarkers. 2013; 18(7):565-72. PMC: 3836424. DOI: 10.3109/1354750X.2013.810667. View

Anson M, Crain-Denoyelle A, Baud V, Chereau F, Gougelet A, Terris B . Oncogenic β-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice. J Clin Invest. 2012; 122(2):586-99. PMC: 3266772. DOI: 10.1172/JCI43937. View

Nejak-Bowen K, Zeng G, Tan X, Cieply B, Monga S . Beta-catenin regulates vitamin C biosynthesis and cell survival in murine liver. J Biol Chem. 2009; 284(41):28115-28127. PMC: 2788862. DOI: 10.1074/jbc.M109.047258. View

Ma H, Shi Y, Zhang X, Li M, Chen J . A transmembrane C-type lectin receptor mediates LECT2 effects on head kidney-derived monocytes/macrophages in a teleost, Plecoglossus altivelis. Fish Shellfish Immunol. 2016; 51:70-76. DOI: 10.1016/j.fsi.2016.02.013. View

Mereuta O, Theis J, Vrana J, Law M, Grogg K, Dasari S . Leukocyte cell-derived chemotaxin 2 (LECT2)-associated amyloidosis is a frequent cause of hepatic amyloidosis in the United States. Blood. 2014; 123(10):1479-82. DOI: 10.1182/blood-2013-07-517938. View

Nakatani Y, Kaneto H, Kawamori D, Hatazaki M, Miyatsuka T, Matsuoka T . Modulation of the JNK pathway in liver affects insulin resistance status. J Biol Chem. 2004; 279(44):45803-9. DOI: 10.1074/jbc.M406963200. View

Lu X, Chen J, Yu C, Shi Y, He Y, Zhang R . LECT2 protects mice against bacterial sepsis by activating macrophages via the CD209a receptor. J Exp Med. 2012; 210(1):5-13. PMC: 3549712. DOI: 10.1084/jem.20121466. View

Yamagoe S, Kameoka Y, Hashimoto K, Mizuno S, Suzuki K . Molecular cloning, structural characterization, and chromosomal mapping of the human LECT2 gene. Genomics. 1998; 48(3):324-9. DOI: 10.1006/geno.1997.5198. View

Cong L, Chen H, Li Y, Zhou L, McGibbon M, Taylor S . Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol Endocrinol. 1998; 11(13):1881-90. DOI: 10.1210/mend.11.13.0027. View

10.

Zhang R, Chen J, Li C, Lu X, Shi Y . Prokaryotic expression, purification, and refolding of leukocyte cell-derived chemotaxin 2 and its effect on gene expression of head kidney-derived macrophages of a teleost fish, ayu (Plecoglossus altivelis). Fish Shellfish Immunol. 2011; 31(6):911-8. DOI: 10.1016/j.fsi.2011.08.008. View

11.

Hirosumi J, Tuncman G, Chang L, Gorgun C, Uysal K, Maeda K . A central role for JNK in obesity and insulin resistance. Nature. 2002; 420(6913):333-6. DOI: 10.1038/nature01137. View

12.

Graessler J, Verlohren M, Graessler A, Zeissig A, Kuhlisch E, Kopprasch S . Association of chondromodulin-II Val58Ile polymorphism with radiographic joint destruction in rheumatoid arthritis. J Rheumatol. 2005; 32(9):1654-61. View

13.

Saito T, Okumura A, Watanabe H, Asano M, Ishida-Okawara A, Sakagami J . Increase in hepatic NKT cells in leukocyte cell-derived chemotaxin 2-deficient mice contributes to severe concanavalin A-induced hepatitis. J Immunol. 2004; 173(1):579-85. DOI: 10.4049/jimmunol.173.1.579. View

14.

Hwang H, Jung T, Hong H, Seo J, Kim S, Kim N . LECT2 induces atherosclerotic inflammatory reaction via CD209 receptor-mediated JNK phosphorylation in human endothelial cells. Metabolism. 2015; 64(9):1175-82. DOI: 10.1016/j.metabol.2015.06.001. View

15.

Hwang H, Jung T, Kim B, Hong H, Seo J, Kim S . A dipeptidyl peptidase-IV inhibitor improves hepatic steatosis and insulin resistance by AMPK-dependent and JNK-dependent inhibition of LECT2 expression. Biochem Pharmacol. 2015; 98(1):157-66. DOI: 10.1016/j.bcp.2015.08.098. View

16.

Okumura A, Suzuki T, Dohmae N, Okabe T, Hashimoto Y, Nakazato K . Identification and assignment of three disulfide bonds in mammalian leukocyte cell-derived chemotaxin 2 by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Biosci Trends. 2010; 3(4):139-43. View

17.

Zheng H, Miyakawa T, Sawano Y, Asano A, Okumura A, Yamagoe S . Crystal Structure of Human Leukocyte Cell-derived Chemotaxin 2 (LECT2) Reveals a Mechanistic Basis of Functional Evolution in a Mammalian Protein with an M23 Metalloendopeptidase Fold. J Biol Chem. 2016; 291(33):17133-42. PMC: 5016117. DOI: 10.1074/jbc.M116.720375. View

18.

Koshimizu Y, Ohtomi M . Regulation of neurite extension by expression of LECT2 and neurotrophins based on findings in LECT2-knockout mice. Brain Res. 2009; 1311:1-11. DOI: 10.1016/j.brainres.2009.11.010. View

19.

MacDonald B, Tamai K, He X . Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell. 2009; 17(1):9-26. PMC: 2861485. DOI: 10.1016/j.devcel.2009.06.016. View

20.

Okabe H, Delgado E, Lee J, Yang J, Kinoshita H, Hayashi H . Role of leukocyte cell-derived chemotaxin 2 as a biomarker in hepatocellular carcinoma. PLoS One. 2014; 9(6):e98817. PMC: 4043833. DOI: 10.1371/journal.pone.0098817. View