[Oral Anticoagulant-associated Intracerebral Haemorrhage]

Overview

Journal Med Klin Intensivmed Notfmed

Specialties Critical Care
General Medicine

Date 2017 May 4

PMID 28466292

Authors

C Beynon

A W Unterberg

Affiliations

Soon will be listed here.

Abstract

Intracerebral haemorrhage during treatment with oral anticoagulants is associated with high rates of morbidity and mortality. Impaired haemostasis can lead to progressive haematomas and, therefore, it should be identified early in order to initiate measures to reverse anticoagulation. Substitution of coagulation factors is essential in the treatment of these patients, but other intensive care measures such as blood pressure control are mandatory as well.

References

Purrucker J, Haas K, Rizos T, Khan S, Wolf M, Hennerici M . Early Clinical and Radiological Course, Management, and Outcome of Intracerebral Hemorrhage Related to New Oral Anticoagulants. JAMA Neurol. 2015; 73(2):169-77. DOI: 10.1001/jamaneurol.2015.3682. View

Huge V . [Critical care management of intracerebral hemorrhage]. Med Klin Intensivmed Notfmed. 2016; 113(3):164-173. DOI: 10.1007/s00063-016-0154-z. View

Connolly S, Milling Jr T, Eikelboom J, Gibson C, Curnutte J, Gold A . Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors. N Engl J Med. 2016; 375(12):1131-41. PMC: 5568772. DOI: 10.1056/NEJMoa1607887. View

Spahn D, Bouillon B, Cerny V, Coats T, Duranteau J, Fernandez-Mondejar E . Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care. 2013; 17(2):R76. PMC: 4056078. DOI: 10.1186/cc12685. View

Dentali F, Marchesi C, Giorgi Pierfranceschi M, Crowther M, Garcia D, Hylek E . Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists. A meta-analysis. Thromb Haemost. 2011; 106(3):429-38. DOI: 10.1160/TH11-01-0052. View

Hylek E, Singer D . Risk factors for intracranial hemorrhage in outpatients taking warfarin. Ann Intern Med. 1994; 120(11):897-902. DOI: 10.7326/0003-4819-120-11-199406010-00001. View

Goldstein J, Refaai M, Milling Jr T, Lewis B, Goldberg-Alberts R, Hug B . Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial. Lancet. 2015; 385(9982):2077-87. PMC: 6633921. DOI: 10.1016/S0140-6736(14)61685-8. View

Beynon C, Sakowitz O, Storzinger D, Orakcioglu B, Radbruch A, Potzy A . Intracranial haemorrhage in patients treated with direct oral anticoagulants. Thromb Res. 2015; 136(3):560-5. DOI: 10.1016/j.thromres.2015.07.001. View

Giugliano R, Ruff C, Braunwald E, Murphy S, Wiviott S, Halperin J . Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2013; 369(22):2093-104. DOI: 10.1056/NEJMoa1310907. View

10.

Hemphill 3rd J, Greenberg S, Anderson C, Becker K, Bendok B, Cushman M . Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2015; 46(7):2032-60. DOI: 10.1161/STR.0000000000000069. View

11.

Pollack Jr C, Reilly P, Eikelboom J, Glund S, Verhamme P, Bernstein R . Idarucizumab for Dabigatran Reversal. N Engl J Med. 2015; 373(6):511-20. DOI: 10.1056/NEJMoa1502000. View

12.

Jonsson A, Spigset O, Jacobsson I, Hagg S . Cerebral haemorrhage induced by warfarin - the influence of drug-drug interactions. Pharmacoepidemiol Drug Saf. 2006; 16(3):309-15. DOI: 10.1002/pds.1291. View

13.

Tanislav C, Milde S, Schwartzkopff S, Sieweke N, Kramer H, Juenemann M . Secondary stroke prevention in atrial fibrillation: a challenge in the clinical practice. BMC Neurol. 2014; 14:195. PMC: 4189749. DOI: 10.1186/s12883-014-0195-y. View

14.

Rohde V, Uzma N, Rohde I, St Clair E, Samadani U . Fibrinolytic therapy versus craniotomy for anticoagulant-associated intracerebral hemorrhage. Clin Neurol Neurosurg. 2009; 111(6):518-22. DOI: 10.1016/j.clineuro.2009.02.004. View

15.

Romualdi E, Micieli E, Ageno W, Squizzato A . Oral anticoagulant therapy in patients with mechanical heart valve and intracranial haemorrhage. A systematic review. Thromb Haemost. 2009; 101(2):290-7. View

16.

Medi C, Hankey G, Freedman S . Stroke risk and antithrombotic strategies in atrial fibrillation. Stroke. 2010; 41(11):2705-13. DOI: 10.1161/STROKEAHA.110.589218. View

17.

Apostolakis S, Lane D, Guo Y, Buller H, Lip G . Performance of the HEMORR(2)HAGES, ATRIA, and HAS-BLED bleeding risk-prediction scores in patients with atrial fibrillation undergoing anticoagulation: the AMADEUS (evaluating the use of SR34006 compared to warfarin or acenocoumarol in patients with.... J Am Coll Cardiol. 2012; 60(9):861-7. DOI: 10.1016/j.jacc.2012.06.019. View

18.

Flordal P, Sahlin S . Use of desmopressin to prevent bleeding complications in patients treated with aspirin. Br J Surg. 1993; 80(6):723-4. DOI: 10.1002/bjs.1800800616. View

19.

Flaherty M, Tao H, Haverbusch M, Sekar P, Kleindorfer D, Kissela B . Warfarin use leads to larger intracerebral hematomas. Neurology. 2008; 71(14):1084-9. PMC: 2668872. DOI: 10.1212/01.wnl.0000326895.58992.27. View

20.

Prabhakaran S, Herbers P, Khoury J, Adeoye O, Khatri P, Ferioli S . Is prophylactic anticoagulation for deep venous thrombosis common practice after intracerebral hemorrhage?. Stroke. 2015; 46(2):369-75. DOI: 10.1161/STROKEAHA.114.008006. View