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Pulmonary Hypertension and Cancer: Etiology, Diagnosis, and Management

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Date 2017 May 4
PMID 28466120
Citations 7
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Abstract

Pulmonary hypertension is caused by cancer and its therapeutic agents including chemotherapy, radiotherapy, and even the targeted therapies. Ironically, some of the cancer therapies that cause one type of pulmonary hypertension (PH) could potentially be employed in the treatment of another PH type. Greater awareness on the role of cancer therapeutic agents in causing PH is required. Conversely, since PH is mostly incurable, the potential role of some of these cancer therapeutic agents in the cure of PH should be recognized. In short, the relationship between cancer, cancer therapy, and PH is an interesting one requiring further attention, education, and research.

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References
1.
Hoeper M, Mayer E, Simonneau G, Rubin L . Chronic thromboembolic pulmonary hypertension. Circulation. 2006; 113(16):2011-20. DOI: 10.1161/CIRCULATIONAHA.105.602565. View

2.
Galie N, Humbert M, Vachiery J, Gibbs S, Lang I, Torbicki A . 2015 ESC/ERS Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension. Rev Esp Cardiol (Engl Ed). 2016; 69(2):177. DOI: 10.1016/j.rec.2016.01.002. View

3.
Ranchoux B, Gunther S, Quarck R, Chaumais M, Dorfmuller P, Antigny F . Chemotherapy-induced pulmonary hypertension: role of alkylating agents. Am J Pathol. 2014; 185(2):356-71. DOI: 10.1016/j.ajpath.2014.10.021. View

4.
Snyder L, Harmon K, Estensen R . Intravascular lymphomatosis (malignant angioendotheliomatosis) presenting as pulmonary hypertension. Chest. 1989; 96(5):1199-200. DOI: 10.1378/chest.96.5.1199. View

5.
Viskochil D, Buchberg A, Xu G, Cawthon R, Stevens J, Wolff R . Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus. Cell. 1990; 62(1):187-92. DOI: 10.1016/0092-8674(90)90252-a. View