Chronic Administration of Tadalafil Improves the Symptoms of Patients with Amicrobic MAGI: An Open Study

Overview

Journal Int J Endocrinol

Publisher Wiley

Specialty Endocrinology

Date 2017 May 4

PMID 28465683

Citations 1

Authors

Sandro La Vignera

Rosita A Condorelli

Laura M Mongioi

Aldo E Calogero

Affiliations

Soon will be listed here.

Abstract

Aim of this study was to evaluate the effects of pharmacological treatment with Tadalafil 5 mg daily on symptoms and quality of sperm parameters in selected patients with amicrobic MAGI (male accessory gland inflammation). 120 patients with amicrobic MAGI (mean age 27.0 ± 6.0 years) with mild-moderate ED (erectile dysfunction) according to IIEF-5 (International Index of Erectile Function 5 Items) scores underwent pharmacological treatment with Tadalafil 5 mg daily for six months. Before and after treatment these patients were evaluated through IIEF-5, semen analysis (according to WHO Criteria, 2010), SI-MAGI (Structured Interview about Male Accessory Gland Inflammation), and ultrasound evaluation. Patients with PVE (prostate-vesciculo-epididymitis) showed a significant increase in the percentage of spermatozoa with total (16.0 ± 8.0 versus 30.0 ± 6.0%) and progressive motility (8.00 ± 10.0 versus 25.0 ± 6.00%). It was a significant reduction of the number of patients with complicated ultrasound forms (30.0 versus 52.0) and a significant increase of the number of patients with uncomplicated ultrasound form (90.0 versus 68.0). Finally, there was a significant reduction in the percentage of patients with alterations of sexual function different from DE, such as premature ejaculation (4.00 versus 8.00%), painful ejaculation (4.00 versus 10.0%), delayed ejaculation (12.50 versus 8.00%), and decreased libido (10.0 versus 25.0%).

Citing Articles

Meta-Analysis of the Long-Term Efficacy and Tolerance of Tadalafil Daily Compared With Tadalafil On-Demand in Treating Men With Erectile Dysfunction.

Zhou Z, Chen H, Wu J, Wang J, Zhang X, Ma J Sex Med. 2019; 7(3):282-291.

PMID: 31307951 PMC: 6728809. DOI: 10.1016/j.esxm.2019.06.006.

References

Takeda M, Tang R, Shapiro E, Burnett A, Lepor H . Effects of nitric oxide on human and canine prostates. Urology. 1995; 45(3):440-6. DOI: 10.1016/S0090-4295(99)80013-2. View

Paduch D, Bolyakov A, Polzer P, Watts S . Effects of 12 weeks of tadalafil treatment on ejaculatory and orgasmic dysfunction and sexual satisfaction in patients with mild to severe erectile dysfunction: integrated analysis of 17 placebo-controlled studies. BJU Int. 2013; 111(2):334-43. DOI: 10.1111/j.1464-410X.2012.11656.x. View

Delavierre D, Sibert L, Rigaud J, Labat J . [Painful ejaculation]. Prog Urol. 2014; 24(7):414-20. DOI: 10.1016/j.purol.2013.11.008. View

Pomara G, Morelli G, Canale D, Turchi P, Caglieresi C, Moschini C . Alterations in sperm motility after acute oral administration of sildenafil or tadalafil in young, infertile men. Fertil Steril. 2007; 88(4):860-5. DOI: 10.1016/j.fertnstert.2006.12.019. View

Burnett A, Maguire M, Chamness S, Ricker D, Takeda M, Lepor H . Characterization and localization of nitric oxide synthase in the human prostate. Urology. 1995; 45(3):435-9. DOI: 10.1016/S0090-4295(99)80012-0. View

La Vignera S . Male accessory gland infections: anatomical extension of inflammation and severity of symptoms evaluated by an original questionnaire. Andrologia. 2012; 44 Suppl 1:739-46. DOI: 10.1111/j.1439-0272.2011.01260.x. View

Grimsley S, Khan M, Jones G . Mechanism of Phosphodiesterase 5 inhibitor relief of prostatitis symptoms. Med Hypotheses. 2007; 69(1):25-6. DOI: 10.1016/j.mehy.2006.11.040. View

Eid A, El Dine F, Nabil I . Histopathologic and Ultrastructural Changes in Seminiferous Tubules of Adult Male Albino Rats Following Daily Administration of Different Doses of Tadalafil. Urology. 2016; 90:89-96. DOI: 10.1016/j.urology.2015.12.038. View

Hellstrom W, Overstreet J, Yu A, Saikali K, Shen W, Beasley Jr C . Tadalafil has no detrimental effect on human spermatogenesis or reproductive hormones. J Urol. 2003; 170(3):887-91. DOI: 10.1097/01.ju.0000081053.97792.da. View

10.

Everaert K, Mahmoud A, Depuydt C, Maeyaert M, Comhaire F . Chronic prostatitis and male accessory gland infection--is there an impact on male infertility (diagnosis and therapy)?. Andrologia. 2003; 35(5):325-30. View

11.

Comhaire F, Verschraegen G, Vermeulen L . Diagnosis of accessory gland infection and its possible role in male infertility. Int J Androl. 1980; 3(1):32-45. DOI: 10.1111/j.1365-2605.1980.tb00093.x. View

12.

Wayman C, Phillips S, Lunny C, Webb T, Fawcett L, Baxendale R . Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology. Int J Impot Res. 2005; 17(3):216-23. DOI: 10.1038/sj.ijir.3901307. View

13.

Corvasce A, Albino G, Leonetti T, Buonomo A, Marucco E . Once-a-day Tadalafil administration improves the spermogram parameters in fertile patients. Arch Ital Urol Androl. 2015; 87(3):210-3. DOI: 10.4081/aiua.2015.3.210. View

14.

La Vignera S, Calogero A, Condorelli R, Vicari L, Catanuso M, DAgata R . Ultrasonographic evaluation of patients with male accessory gland infection. Andrologia. 2011; 44 Suppl 1:26-31. DOI: 10.1111/j.1439-0272.2010.01132.x. View

15.

Ozcan L, Polat E, Onen E, Kocaaslan R, Otunctemur A, Cekmen M . Effects of Tadalafil 5 mg Dosed Once Daily in Men with Premature Ejaculation. Urol Int. 2016; 98(2):210-214. DOI: 10.1159/000445839. View

16.

La Vignera S, Vicari E, Condorelli R, DAgata R, Calogero A . Hypertrophic-congestive and fibro-sclerotic ultrasound variants of male accessory gland infection have different sperm output. J Endocrinol Invest. 2012; 34(10):e330-5. DOI: 10.1007/BF03346729. View

17.

Carosa E, Martini P, Brandetti F, Stasi S, Lombardo F, Lenzi A . Type V phosphodiesterase inhibitor treatments for erectile dysfunction increase testosterone levels. Clin Endocrinol (Oxf). 2004; 61(3):382-6. DOI: 10.1111/j.1365-2265.2004.02108.x. View

18.

Ilie C, Mischianu D, Pemberton R . Painful ejaculation. BJU Int. 2007; 99(6):1335-9. DOI: 10.1111/j.1464-410X.2007.06664.x. View

19.

La Vignera S . Seminal vesicles of infertile patients with male accessory gland infection: ultrasound evaluation after prolonged treatment with tadalafil, a selective phosphodiesterase-5 inhibitor. Andrologia. 2012; 45(6):386-91. DOI: 10.1111/and.12027. View

20.

Kirby R, Carson 3rd C, Dasgupta P . Daily phosphodiesterase type 5 inhibitor therapy: a new treatment option for prostatitis/prostatodynia?. BJU Int. 2014; 113(5):694-5. DOI: 10.1111/bju.12681. View