Prognostic Value of MLH1 Promoter Methylation in Male Patients with Esophageal Squamous Cell Carcinoma

Overview

Journal Oncol Lett

Specialty Oncology

Date 2017 Apr 30

PMID 28454461

Citations 7

Authors

Dongping Wu

Xiaoying Chen

Yan Xu

Haiyong Wang

Guangmao Yu

Luping Jiang

Qingxiao Hong

Shiwei Duan

Affiliations

Soon will be listed here.

Abstract

The DNA mismatch repair (MMR) gene MutL homolog 1 () is critical for the maintenance of genomic integrity. Methylation of the gene promoter was identified as a prognostic marker for numerous types of cancer including glioblastoma, colorectal, ovarian and gastric cancer. The present study aimed to determine whether promoter methylation was associated with survival in male patients with esophageal squamous cell carcinoma (ESCC). Formalin-fixed, paraffin-embedded ESCC tissues were collected from 87 male patients. promoter methylation was assessed using the methylation-specific polymerase chain reaction approach. Kaplan-Meier survival curves and log-rank tests were used to evaluate the association between promoter methylation and overall survival (OS) in patients with ESCC. Cox regression analysis was used to obtain crude and multivariate hazard ratios (HR), and 95% confidence intervals (CI). The present study revealed that promoter methylation was observed in 53/87 (60.9%) of male patients with ESCC. Kaplan-Meier survival analysis demonstrated that promoter hypermethylation was significantly associated with poorer prognosis in patients with ESCC (P=0.048). Multivariate survival analysis revealed that promoter hypermethylation was an independent predictor of poor OS in male patients with ESCC (HR=1.716; 95% CI=1.008-2.921). Therefore, promoter hypermethylation may be a predictor of prognosis in male patients with ESCC.

Citing Articles

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