Associations Between Cytokine Gene Polymorphisms and Susceptibility to Helicobacter Pylori Infection and Helicobacter Pylori Related Gastric Cancer, Peptic Ulcer Disease: A Meta-analysis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2017 Apr 29

PMID 28453551

Citations 18

Authors

Jingjing Ma

Dandan Wu

Xue Hu

Jiao Li

Mingwei Cao

Weiguo Dong

Affiliations

Soon will be listed here.

Abstract

Objectives: The aim of this study is to clarify the associations between IL-1B31C/T, IL-1B-511C/T, IL-8-251T/A gene polymorphisms and the risk of Helicobacter pylori (H. pylori) infection together with H. pylori-related gastric cancer (GC), peptic ulcer disease (PUD).

Methods: All eligible literature published up to July 2016 were identified by searching Pubmed, Embase, Web of Science and CNKI. Pooled odds ratio (OR) and 95% confidence interval (95% CI) were calculated using a fixed or random effects model.

Results: 29 case-control studies were eligible, and each of them may focus on more than one gene polymorphism. Ultimately, there were 21 studies (3159 cases and 2816 controls) for IL-1B-31C/T, 16 studies (2486 cases and 1989 controls) for IL-1B-511C/T polymorphisms, 9 studies (1963 cases and 1205 controls) for IL-8-251T/A polymorphisms. Overall, an increased risk of H. pylori infection was found for IL-1B-31C/T polymorphisms in total population [OR = 1.134, 95%CI = 1.008-1.275 for recessive model; OR = 1.145, 95%CI = 1.007-1.301 for TT vs CC model]. While, for IL-1B-511C/T and IL8-251T/A polymorphisms, no evidence indicated that they were associated with the risk of H. pylori infection in all genetic models. Furthermore, we found an increased risk of H. pylori-related GC with IL-1B-511C/T polymorphisms [OR = 1.784, 95%CI = 1.289-2.469 for recessive model; OR = 1.772, 95%CI = 1.210-2.594 for TT vs CC model] and IL8-251A/T polymorphisms [OR = 1.810, 95%CI = 1.229-2.667 for recessive model; OR = 1.717, 95%CI = 1.143-2.580 for TT vs AA model], an increased risk of H. pylori-related PUD with IL8-251T/A polymorphisms [OR = 1.364, 95%CI = 1.010-1.843 for recessive model; OR = 1.427, 95%CI = 1.039-1.959 for AA vs TT model].

Conclusions: IL-1B-31C/T gene polymorphisms might increase H. pylori infection risk. IL-1B-511-C/T and IL-8-251T/A gene polymorphisms might act as a risk factor to H. pylori-related diseases including GC or PUD.

Citing Articles

Prior Helicobacter Pylori Infection is Associated with Improved Survival for Hispanic Patients with Gastric Cancer.

Liu P, Box 3rd E, Patel M, Franceschi D, Livingstone A, Merchant N Ann Surg Oncol. 2024; 32(3):1425-1428.

PMID: 39739261 DOI: 10.1245/s10434-024-16658-y.

Exploring the Relationship Between Helicobacter pylori Infection and Biliary Diseases: A Comprehensive Analysis Using the United States National Inpatient Sample (2016-2020).

Ahmad S, AlAmr M, Taftafa A, AlMazmomy A, Alkahmous N, Alharran A Cureus. 2024; 16(5):e61238.

PMID: 38939288 PMC: 11210440. DOI: 10.7759/cureus.61238.

Mutations in Helicobacter pylori infected patients with chronic gastritis, intestinal type of gastric cancer and familial gastric cancer.

Hnatyszyn A, Szalata M, Zielinska A, Wielgus K, Danielewski M, Hnatyszyn P Hered Cancer Clin Pract. 2024; 22(1):9.

PMID: 38867324 PMC: 11167877. DOI: 10.1186/s13053-024-00282-8.

Global burden of gastric cancer: epidemiological trends, risk factors, screening and prevention.

Thrift A, Wenker T, El-Serag H Nat Rev Clin Oncol. 2023; 20(5):338-349.

PMID: 36959359 DOI: 10.1038/s41571-023-00747-0.

Anti-Oxidant and Anti-Inflammatory Effects of Astaxanthin on Gastrointestinal Diseases.

Lee J, Kim M, Kim H Int J Mol Sci. 2022; 23(24).

PMID: 36555112 PMC: 9779521. DOI: 10.3390/ijms232415471.

References

Chang Y, Jang J, Kim N, Lee J, Lee H, Jung W . Interleukin-1B (IL-1B) polymorphisms and gastric mucosal levels of IL-1beta cytokine in Korean patients with gastric cancer. Int J Cancer. 2004; 114(3):465-71. DOI: 10.1002/ijc.20724. View

Sugimoto M, Furuta T, Yamaoka Y . Influence of inflammatory cytokine polymorphisms on eradication rates of Helicobacter pylori. J Gastroenterol Hepatol. 2010; 24(11):1725-32. PMC: 3128255. DOI: 10.1111/j.1440-1746.2009.06047.x. View

Kang W, Park W, Chin H, Park C . [The role of interleukin-1beta gene polymorphism in the gastric carcinogenesis]. Korean J Gastroenterol. 2004; 44(1):25-33. View

Waghray M, Zavros Y, Saqui-Salces M, El-Zaatari M, Alamelumangapuram C, Todisco A . Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog. Gastroenterology. 2009; 138(2):562-72, 572.e1-2. PMC: 2895809. DOI: 10.1053/j.gastro.2009.10.043. View

Li C, Hua-Xiang Xia H, Xie W, Hu Z, Ye M, Li J . Association between interleukin-1 gene polymorphisms and Helicobacter pylori infection in gastric carcinogenesis in a Chinese population. J Gastroenterol Hepatol. 2007; 22(2):234-9. DOI: 10.1111/j.1440-1746.2006.04379.x. View

He B, Pan Y, Xu Y, Zhu C, Qu L, Wang S . Polymorphisms in interleukin-1B (IL-1B) and interleukin 1 receptor antagonist (IL-1RN) genes associate with gastric cancer risk in the Chinese population. Dig Dis Sci. 2011; 56(7):2017-23. DOI: 10.1007/s10620-010-1557-y. View

Katsuda N, Hamajima N, Tamakoshi A, Wakai K, Matsuo K, Saito T . Helicobacter pylori seropositivity and the myeloperoxidase G-463A polymorphism in combination with interleukin-1B C-31T in Japanese health checkup examinees. Jpn J Clin Oncol. 2003; 33(4):192-7. DOI: 10.1093/jjco/hyg034. View

Higgins J, Thompson S . Quantifying heterogeneity in a meta-analysis. Stat Med. 2002; 21(11):1539-58. DOI: 10.1002/sim.1186. View

Ying H, Yu B, Yang Z, Yang S, Bo L, Shan X . Interleukin-1B 31 C>T polymorphism combined with Helicobacter pylori-modified gastric cancer susceptibility: evidence from 37 studies. J Cell Mol Med. 2016; 20(3):526-36. PMC: 4759475. DOI: 10.1111/jcmm.12737. View

10.

Queiroz D, Saraiva I, Rocha G, Rocha A, Gomes L, Melo F . IL2-330G polymorphic allele is associated with decreased risk of Helicobacter pylori infection in adulthood. Microbes Infect. 2009; 11(12):980-7. DOI: 10.1016/j.micinf.2009.07.008. View

11.

Kimanga A . IL-1B-511 Allele T and IL-1RN-L/L Play a Pathological Role in Helicobacter Pylori (H. Pylori) Disease Outcome in the African Population. Ethiop J Health Sci. 2012; 22(3):163-9. PMC: 3511894. View

12.

Neto A, Rasmussen L, de Labio R, de Queiroz V, Smith M, Viani G . Gene polymorphism of interleukin 1 and 8 in chronic gastritis patients infected with Helicobacter pylori. J Venom Anim Toxins Incl Trop Dis. 2014; 20:17. PMC: 4011515. DOI: 10.1186/1678-9199-20-17. View

13.

Wang M, Furuta T, Takashima M, Futami H, Shirai N, Hanai H . Relation between interleukin-1beta messenger RNA in gastric fundic mucosa and gastric juice pH in patients infected with Helicobacter pylori. J Gastroenterol. 2000; 34 Suppl 11:10-7. View

14.

Begg C, Mazumdar M . Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994; 50(4):1088-101. View

15.

Uno M, Hamajima N, Ito L, Oba S, Marie S, Shinjo S . Helicobacter pylori seropositivity and IL-1B C-31T polymorphism among Japanese Brazilians. Int J Mol Med. 2002; 10(3):321-6. View

16.

Kumar S, Kumar A, Dixit V . Evidences showing association of interleukin-1B polymorphisms with increased risk of gastric cancer in an Indian population. Biochem Biophys Res Commun. 2009; 387(3):456-60. DOI: 10.1016/j.bbrc.2009.07.033. View

17.

Ohyauchi M, Imatani A, Yonechi M, Asano N, Miura A, Iijima K . The polymorphism interleukin 8 -251 A/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population. Gut. 2005; 54(3):330-5. PMC: 1774396. DOI: 10.1136/gut.2003.033050. View

18.

Risch H, Lu L, Kidd M, Wang J, Zhang W, Ni Q . Helicobacter pylori seropositivities and risk of pancreatic carcinoma. Cancer Epidemiol Biomarkers Prev. 2013; 23(1):172-8. PMC: 3947155. DOI: 10.1158/1055-9965.EPI-13-0447. View

19.

Miftahussurur M, Yamaoka Y . Helicobacter pylori virulence genes and host genetic polymorphisms as risk factors for peptic ulcer disease. Expert Rev Gastroenterol Hepatol. 2015; 9(12):1535-47. PMC: 5332543. DOI: 10.1586/17474124.2015.1095089. View

20.

Farshad S, Rasouli M, Jamshidzadeh A, Hosseinkhani A, Japoni A, Alborzi A . IL-1ß (+3953 C/T) and IL-8 (-251 A/T) gene polymorphisms in H. pylori mediated gastric disorders. Iran J Immunol. 2010; 7(2):96-108. DOI: IJIv7i2A5. View