Antibiotic Resistance: What is So Special About Multidrug-resistant Gram-negative Bacteria?

Overview

Journal GMS Hyg Infect Control

Specialty Health Services

Date 2017 Apr 29

PMID 28451516

Citations 156

Authors

Martin Exner

Sanjay Bhattacharya

Barbel Christiansen

Jurgen Gebel

Peter Goroncy-Bermes

Philippe Hartemann

Peter Heeg

Carola Ilschner

Axel Kramer

Elaine Larson

Wolfgang Merkens

Martin Mielke

Peter Oltmanns

Birgit Ross

Manfred Rotter

Ricarda Maria Schmithausen

Hans-Gunther Sonntag

Matthias Trautmann

Affiliations

Soon will be listed here.

Abstract

In the past years infections caused by multidrug-resistant Gram-negative bacteria have dramatically increased in all parts of the world. This consensus paper is based on presentations, subsequent discussions and an appraisal of current literature by a panel of international experts invited by the Rudolf Schülke Stiftung, Hamburg. It deals with the epidemiology and the inherent properties of Gram-negative bacteria, elucidating the patterns of the spread of antibiotic resistance, highlighting reservoirs as well as transmission pathways and risk factors for infection, mortality, treatment and prevention options as well as the consequences of their prevalence in livestock. Following a global, One Health approach and based on the evaluation of the existing knowledge about these pathogens, this paper gives recommendations for prevention and infection control measures as well as proposals for various target groups to tackle the threats posed by Gram-negative bacteria and prevent the spread and emergence of new antibiotic resistances.

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