A Randomized Controlled Trial Study on the Effect of Adding Dexmedetomidine to Bupivacaine in Supraclavicular Block Using Ultrasound Guidance

Overview

Journal Ethiop J Health Sci

Specialty Health Services

Date 2017 Apr 29

PMID 28450772

Citations 4

Authors

Nazia Nazir

Shruti Jain

Affiliations

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Abstract

Background: The benefits of regional anesthetic techniques are well established. Use of additives to local anesthetics can prolong these benefits. The aim of this study was to find out the effect of adding dexmedetomidine to bupivacaine for supraclavicular block.

Methods: In this randomized, double-blind study, 70 ASA I & II patients of either sex undergoing elective surgeries on the upper limb were given supraclavicular block under ultrasound guidance. Group C (n=35) received 38 mL 0.25% bupivacaine + 2mL normal saline and group D received 38 mL 0.25% bupivacaine + 1 µg/kg dexmedetomidine (2mL). Patients were observed for, onset of motor and sensory block, duration of motor and sensory block, duration of analgesia, sedation score, hemodynamic changes and any adverse events.

Results: In group D, the onset was faster (P< 0.001), durations of sensory and motor block duration of and analgesia were prolonged as compared to group C (P < 0.0001).There was a significant drop in heart rate (HR) from the baseline in group D (P < 0.05) at 30, 60, 90 and 120 min. However, none of the patients dropped HR below 50/min. Mean Arterial Pressure (MAP) remained unaffected. The patients in group D were more effectively sedated than those in group C (P < 0.05). No adverse event was reported in either group.

Conclusion: Dexmedetomidine as adjuvant to bupivacaine in supraclavicular block resulted in faster action, prolonged motor and sensory block, prolonged analgesia with hemodynamic stability and adequate sedation.

Citing Articles

Dexmedetomidine as an Adjuvant in Peripheral Nerve Block.

Chen Z, Liu Z, Feng C, Jin Y, Zhao X Drug Des Devel Ther. 2023; 17:1463-1484.

PMID: 37220544 PMC: 10200118. DOI: 10.2147/DDDT.S405294.

Optimal dose of perineural dexmedetomidine to prolong analgesia after brachial plexus blockade: a systematic review and Meta-analysis of 57 randomized clinical trials.

Cai H, Fan X, Feng P, Wang X, Xie Y BMC Anesthesiol. 2021; 21(1):233.

PMID: 34583650 PMC: 8477554. DOI: 10.1186/s12871-021-01452-0.

Dexmedetomidine versus sufentanil as adjuvants to bupivacaine for brachial plexus block during upper extremity surgery: a randomized clinical trial.

Ghasemi A, Chamanara M, Paknejad B, Yousefizoshk M, Hazrati E Braz J Anesthesiol. 2021; 73(6):736-743.

PMID: 33932394 PMC: 10625153. DOI: 10.1016/j.bjane.2021.03.026.

The Effect of Dexmedetomidine in Combination with Bupivacaine on Sensory and Motor Block Time and Pain Score in Supraclavicular Block.

Sane S, Shokouhi S, Golabi P, Rezaeian M, Kazemi Haki B Pain Res Manag. 2021; 2021:8858312.

PMID: 33927790 PMC: 8053064. DOI: 10.1155/2021/8858312.

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