HIF-prolyl Hydroxylases As Therapeutic Targets in Erythropoiesis and Iron Metabolism

Overview

Journal Hemodial Int

Date 2017 Apr 28

PMID 28449418

Citations 84

Authors

Volker H Haase

Affiliations

Soon will be listed here.

Abstract

A classic response to systemic hypoxia is the increase in red blood cell production. This response is controlled by the prolyl hydroxylase domain/hypoxia-inducible factor (HIF) pathway, which regulates a broad spectrum of cellular functions. The discovery of this pathway as a key regulator of erythropoiesis has led to the development of small molecules that stimulate the production of endogenous erythropoietin and enhance iron metabolism. This review provides a concise overview of the cellular and molecular mechanisms that govern HIF-induced erythropoietic responses and provides an update on clinical experience with compounds that target HIF-prolyl hydroxylases for anemia therapy.

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