Role of Circulating Factors in Cardiac Aging

Overview

Journal J Thorac Dis

Publisher AME Publishing Company

Specialty Pulmonary Medicine

Date 2017 Apr 28

PMID 28446965

Citations 12

Authors

Antonio Cannata

Gabriella Marcon

Giovanni Cimmino

Luca Camparini

Giulio Ciucci

Gianfranco Sinagra

Francesco S Loffredo

Affiliations

Soon will be listed here.

Abstract

Worldwide increase in life expectancy is a major contributor to the epidemic of chronic degenerative diseases. Aging, indeed, simultaneously affects multiple organ systems, and it has been hypothesized that systemic alterations in regulators of tissue physiology may regulate this process. Cardiac aging itself is a major risk factor for cardiovascular diseases and, because of the intimate relationship with the brain, may contribute to increase the risk of neurodegenerative disorders. Blood-borne factors may play a major role in this complex and still elusive process. A number of studies, mainly based on the revival of parabiosis, a surgical technique very popular during the 70s of the 20 century to study the effect of a shared circulation in two animals, have indeed shown the potential that humoral factors can control the aging process in different tissues. In this article we review the role of circulating factors in cardiovascular aging. A better understanding of these mechanisms may provide new insights in the aging process and provide novel therapeutic opportunities for chronic age-related disorders.

Citing Articles

Young blood-mediated cerebromicrovascular rejuvenation through heterochronic parabiosis: enhancing blood-brain barrier integrity and capillarization in the aged mouse brain.

Gulej R, Nyul-Toth A, Csik B, Patai R, Petersen B, Negri S Geroscience. 2024; 46(5):4415-4442.

PMID: 38727872 PMC: 11336025. DOI: 10.1007/s11357-024-01154-8.

Rejuvenation of cerebromicrovascular function in aged mice through heterochronic parabiosis: insights into neurovascular coupling and the impact of young blood factors.

Gulej R, Nyul-Toth A, Csik B, Petersen B, Faakye J, Negri S Geroscience. 2023; 46(1):327-347.

PMID: 38123890 PMC: 10828280. DOI: 10.1007/s11357-023-01039-2.

Rejuvenating effects of young extracellular vesicles in aged rats and in cellular models of human senescence.

Grigorian Shamagian L, Rogers R, Luther K, Angert D, Echavez A, Liu W Sci Rep. 2023; 13(1):12240.

PMID: 37507448 PMC: 10382547. DOI: 10.1038/s41598-023-39370-5.

Extracellular Matrix in Aging Aorta.

Mammoto A, Matus K, Mammoto T Front Cell Dev Biol. 2022; 10:822561.

PMID: 35265616 PMC: 8898904. DOI: 10.3389/fcell.2022.822561.

Old blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling.

Kiss T, Nyul-Toth A, Gulej R, Tarantini S, Csipo T, Mukli P Geroscience. 2022; 44(2):953-981.

PMID: 35124764 PMC: 9135944. DOI: 10.1007/s11357-022-00519-1.

References

Vasan R . Biomarkers of cardiovascular disease: molecular basis and practical considerations. Circulation. 2006; 113(19):2335-62. DOI: 10.1161/CIRCULATIONAHA.104.482570. View

Troncone L, Luciani M, Coggins M, Wilker E, Ho C, Codispoti K . Aβ Amyloid Pathology Affects the Hearts of Patients With Alzheimer's Disease: Mind the Heart. J Am Coll Cardiol. 2016; 68(22):2395-2407. PMC: 5142757. DOI: 10.1016/j.jacc.2016.08.073. View

Wang H, Bei Y, Shi J, Xiao J, Kong X . Non-Coding RNAs in Cardiac Aging. Cell Physiol Biochem. 2015; 36(5):1679-87. DOI: 10.1159/000430141. View

Richards J, Valdes A, Gardner J, Paximadas D, Kimura M, Nessa A . Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. Am J Clin Nutr. 2007; 86(5):1420-5. PMC: 2196219. DOI: 10.1093/ajcn/86.5.1420. View

Thomas C, McAllen R, Salo L, Woods R . Restorative effect of atrial natriuretic peptide or chronic neutral endopeptidase inhibition on blunted cardiopulmonary vagal reflexes in aged rats. Hypertension. 2008; 52(4):696-701. DOI: 10.1161/HYPERTENSIONAHA.108.111302. View

Bruunsgaard H, Pedersen B . Age-related inflammatory cytokines and disease. Immunol Allergy Clin North Am. 2003; 23(1):15-39. DOI: 10.1016/s0889-8561(02)00056-5. View

Maggio M, Guralnik J, Longo D, Ferrucci L . Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol A Biol Sci Med Sci. 2006; 61(6):575-84. PMC: 2645627. DOI: 10.1093/gerona/61.6.575. View

Loffredo F, Nikolova A, Pancoast J, Lee R . Heart failure with preserved ejection fraction: molecular pathways of the aging myocardium. Circ Res. 2014; 115(1):97-107. PMC: 4094348. DOI: 10.1161/CIRCRESAHA.115.302929. View

Buglioni A, Burnett Jr J . Pathophysiology and the cardiorenal connection in heart failure. Circulating hormones: biomarkers or mediators. Clin Chim Acta. 2014; 443:3-8. PMC: 4355214. DOI: 10.1016/j.cca.2014.10.027. View

10.

Hickman R, Faustin A, Wisniewski T . Alzheimer Disease and Its Growing Epidemic: Risk Factors, Biomarkers, and the Urgent Need for Therapeutics. Neurol Clin. 2016; 34(4):941-953. PMC: 5116320. DOI: 10.1016/j.ncl.2016.06.009. View

11.

Herbeth B, Siest G, Henny J . High sensitivity C-reactive protein (CRP) reference intervals in the elderly. Clin Chem Lab Med. 2002; 39(11):1169-70. DOI: 10.1515/CCLM.2001.184. View

12.

Lipsitz L, Habtemariam D, Gagnon M, Iloputaife I, Sorond F, Tchalla A . Reexamining the Effect of Antihypertensive Medications on Falls in Old Age. Hypertension. 2015; 66(1):183-9. PMC: 4465868. DOI: 10.1161/HYPERTENSIONAHA.115.05513. View

13.

Ammarguellat F, Gannon P, Amiri F, Schiffrin E . Fibrosis, matrix metalloproteinases, and inflammation in the heart of DOCA-salt hypertensive rats: role of ET(A) receptors. Hypertension. 2002; 39(2 Pt 2):679-84. DOI: 10.1161/hy0202.103481. View

14.

Chiao Y . MicroRNA-34a: a new piece in the cardiac aging puzzle. Circ Cardiovasc Genet. 2013; 6(4):437-8. DOI: 10.1161/CIRCGENETICS.113.000277. View

15.

Conboy M, Conboy I, Rando T . Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity. Aging Cell. 2013; 12(3):525-30. PMC: 4072458. DOI: 10.1111/acel.12065. View

16.

Redfield M, Rodeheffer R, Jacobsen S, Mahoney D, Bailey K, Burnett Jr J . Plasma brain natriuretic peptide concentration: impact of age and gender. J Am Coll Cardiol. 2002; 40(5):976-82. DOI: 10.1016/s0735-1097(02)02059-4. View

17.

Lee S, Ahuja V, Masaki K, Evans R, Barinas-Mitchell E, Ueshima H . A Significant Positive Association of Vitamin D Deficiency with Coronary Artery Calcification among Middle-aged Men: For the ERA JUMP Study. J Am Coll Nutr. 2016; 35(7):614-620. PMC: 5093044. DOI: 10.1080/07315724.2015.1118651. View

18.

Chen C, Nakayama M, Nevo E, Fetics B, Maughan W, Kass D . Coupled systolic-ventricular and vascular stiffening with age: implications for pressure regulation and cardiac reserve in the elderly. J Am Coll Cardiol. 1998; 32(5):1221-7. DOI: 10.1016/s0735-1097(98)00374-x. View

19.

Wang M, Zhang J, Walker S, Dworakowski R, Lakatta E, Shah A . Involvement of NADPH oxidase in age-associated cardiac remodeling. J Mol Cell Cardiol. 2010; 48(4):765-72. PMC: 2877878. DOI: 10.1016/j.yjmcc.2010.01.006. View

20.

Redfield M, Jacobsen S, Borlaug B, Rodeheffer R, Kass D . Age- and gender-related ventricular-vascular stiffening: a community-based study. Circulation. 2005; 112(15):2254-62. DOI: 10.1161/CIRCULATIONAHA.105.541078. View