Identification of Key Proteins and Pathways in Cadmium Tolerance of Lactobacillus Plantarum Strains by Proteomic Analysis

Overview

Journal Sci Rep

Specialty Science

Date 2017 Apr 28

PMID 28446769

Citations 16

Authors

Qixiao Zhai

Yue Xiao

Jianxin Zhao

Fengwei Tian

Hao Zhang

Arjan Narbad

Wei Chen

Affiliations

Soon will be listed here.

Abstract

Our previous study confirmed the protective potential of Lactobacillus plantarum (L. plantarum) strains in alleviation of cadmium (Cd) toxicity in vivo and demonstrated that the observed protection largely depended on the tolerance of the strains to Cd-induced stress. It was also observed that there were significant intra-species differences in Cd tolerance of L. plantarum strains. In this study, we investigated the mechanism of Cd induced stress response of L. plantarum strains using the isobaric tags for relative and absolute quantitation (iTRAQ) based comparative proteomics. L. plantarum CCFM8610 (strongly resistant to Cd) and L. plantarum CCFM191 (sensitive to Cd) were selected as target strains, and their proteomic profiles in the presence and absence of Cd exposure were compared. We propose that the underlying mechanism of the exceptional Cd tolerance of CCFM8610 may be attributed to the following: (a) a specific energy-conservation survival mode; (b) mild induction of its cellular defense and repair system;

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