Brain Metastases from Hepatocellular Carcinoma: Recent Advances and Future Avenues

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Apr 28

PMID 28445959

Citations 16

Authors

Shanshan Wang

Anqiang Wang

Jianzhen Lin

Yuan Xie

Liangcai Wu

Hanchun Huang

Jin Bian

Xiaobo Yang

Xueshuai Wan

Haitao Zhao

Jiefu Huang

Affiliations

Soon will be listed here.

Abstract

The incidence of brain metastases from hepatocellular carcinoma (BMHCC) is becoming more frequent than that of the past as a result of prolonged survival of patients with HCC. Compared with brain metastases from other types of cancer, BMHCC tends to exhibit a high incidence of intracerebral hemorrhage (ICH) and poor liver function. Unfortunately, the prognosis is extremely poor for patients with BMHCC owing to the limited treatment selection. Currently, optimal treatment requires multidisciplinary approaches including surgery, whole-brain radiation therapy and stereotactic radiosurgery. Besides these traditional approaches, novel treatments such as target therapy and immunotherapy provide an opportunity to improve the survival of these patients. This review provides an overview of the incidence, characteristics, prognosis, and current and potential future management strategies for BMHCC.

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References

Anders C, Deal A, Miller C, Khorram C, Meng H, Burrows E . The prognostic contribution of clinical breast cancer subtype, age, and race among patients with breast cancer brain metastases. Cancer. 2011; 117(8):1602-11. PMC: 4265570. DOI: 10.1002/cncr.25746. View

Natsuizaka M, Omura T, Akaike T, Kuwata Y, Yamazaki K, Sato T . Clinical features of hepatocellular carcinoma with extrahepatic metastases. J Gastroenterol Hepatol. 2005; 20(11):1781-7. DOI: 10.1111/j.1440-1746.2005.03919.x. View

Barnholtz-Sloan J, Yu C, Sloan A, Vengoechea J, Wang M, Dignam J . A nomogram for individualized estimation of survival among patients with brain metastasis. Neuro Oncol. 2012; 14(7):910-8. PMC: 3379797. DOI: 10.1093/neuonc/nos087. View

Dieterich S, Gibbs I . The CyberKnife in clinical use: current roles, future expectations. Front Radiat Ther Oncol. 2011; 43:181-194. DOI: 10.1159/000322423. View

Llovet J, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc J . Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008; 359(4):378-90. DOI: 10.1056/NEJMoa0708857. View

Han J, Kim D, Park J, Chung H, Paek S, Chung Y . Little response of cerebral metastasis from hepatocellular carcinoma to any treatments. J Korean Neurosurg Soc. 2010; 47(5):325-31. PMC: 2883051. DOI: 10.3340/jkns.2010.47.5.325. View

Peters S, Bexelius C, Munk V, Leighl N . The impact of brain metastasis on quality of life, resource utilization and survival in patients with non-small-cell lung cancer. Cancer Treat Rev. 2016; 45:139-62. DOI: 10.1016/j.ctrv.2016.03.009. View

Han J, Kim D, Chung H, Paek S, Park C, Kim C . Stereotactic radiosurgery for brain metastases from hepatocellular carcinoma. J Neurooncol. 2013; 115(1):45-51. DOI: 10.1007/s11060-013-1192-5. View

Radbill A, Fiveash J, Falkenberg E, Guthrie B, Young P, Meleth S . Initial treatment of melanoma brain metastases using gamma knife radiosurgery: an evaluation of efficacy and toxicity. Cancer. 2004; 101(4):825-33. DOI: 10.1002/cncr.20447. View

10.

Katyal S, Oliver 3rd J, Peterson M, Ferris J, Carr B, BARON R . Extrahepatic metastases of hepatocellular carcinoma. Radiology. 2000; 216(3):698-703. DOI: 10.1148/radiology.216.3.r00se24698. View

11.

Won Y, Lee J, Kang Y, Jang J, Kang J, Jung S . Stereotactic radiosurgery for brain metastasis in non-small cell lung cancer. Radiat Oncol J. 2015; 33(3):207-16. PMC: 4607574. DOI: 10.3857/roj.2015.33.3.207. View

12.

Gorantla V, Kirkwood J, Tawbi H . Melanoma brain metastases: an unmet challenge in the era of active therapy. Curr Oncol Rep. 2013; 15(5):483-91. PMC: 3801214. DOI: 10.1007/s11912-013-0335-3. View

13.

Jiang S, Tang Y, Zhang Y, Weng D, Zhou Z, Pan K . A phase I clinical trial utilizing autologous tumor-infiltrating lymphocytes in patients with primary hepatocellular carcinoma. Oncotarget. 2015; 6(38):41339-49. PMC: 4747409. DOI: 10.18632/oncotarget.5463. View

14.

Park E, Kwon D, Park J, Lee D, Cho Y, Kim J . Gamma Knife surgery for treating brain metastases arising from hepatocellular carcinomas. J Neurosurg. 2014; 121 Suppl:102-9. DOI: 10.3171/2014.7.GKS141507. View

15.

McKee M, Keith K, Deal A, Garrett A, Wheless A, Green R . A Multidisciplinary Breast Cancer Brain Metastases Clinic: The University of North Carolina Experience. Oncologist. 2015; 21(1):16-20. PMC: 4709216. DOI: 10.1634/theoncologist.2015-0328. View

16.

Schuette W . Treatment of brain metastases from lung cancer: chemotherapy. Lung Cancer. 2004; 45 Suppl 2:S253-7. DOI: 10.1016/j.lungcan.2004.07.967. View

17.

Ohri N, Kaubisch A, Garg M, Guha C . Targeted Therapy for Hepatocellular Carcinoma. Semin Radiat Oncol. 2016; 26(4):338-43. DOI: 10.1016/j.semradonc.2016.06.004. View

18.

Alvarado G, Noor R, Bassett R, Papadopoulos N, Kim K, Hwu W . Risk of intracranial hemorrhage with anticoagulation therapy in melanoma patients with brain metastases. Melanoma Res. 2012; 22(4):310-5. PMC: 4105847. DOI: 10.1097/CMR.0b013e328353efd8. View

19.

Xu Q, Wu P, Feng Y, Ye K, Tong Y, Zhou Y . Gamma knife surgery for brain metastasis from hepatocellular carcinoma. PLoS One. 2014; 9(2):e88317. PMC: 3917852. DOI: 10.1371/journal.pone.0088317. View

20.

Seoane J, De Mattos-Arruda L . Brain metastasis: new opportunities to tackle therapeutic resistance. Mol Oncol. 2014; 8(6):1120-31. PMC: 5528619. DOI: 10.1016/j.molonc.2014.05.009. View