Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2017 Apr 27

PMID 28443329

Citations 41

Authors

Johannes F P Colell

Meike Emondts

Angus W J Logan

Kun Shen

Junu Bae

Roman V Shchepin

Gerardo X Ortiz Jr

Peter Spannring

Qiu Wang

Steven J Malcolmson

Eduard Y Chekmenev

Martin C Feiters

Floris P J T Rutjes

Bernhard Blumich

Thomas Theis

Warren S Warren

Affiliations

Soon will be listed here.

Abstract

Signal amplification by reversible exchange (SABRE) is an inexpensive, fast, and even continuous hyperpolarization technique that uses para-hydrogen as hyperpolarization source. However, current SABRE faces a number of stumbling blocks for translation to biochemical and clinical settings. Difficulties include inefficient polarization in water, relatively short-lived H-polarization, and relatively limited substrate scope. Here we use a water-soluble polarization transfer catalyst to hyperpolarize nitrogen-15 in a variety of molecules with SABRE-SHEATH (SABRE in shield enables alignment transfer to heteronuclei). This strategy works in pure HO or DO solutions, on substrates that could not be hyperpolarized in traditional H-SABRE experiments, and we record N T relaxation times of up to 2 min.

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