Parathyroidectomy Decreases Insulin Resistance Index in Patients with Primary Hyperparathyroidism

Overview

Journal Indian J Surg

Specialty General Surgery

Date 2017 Apr 27

PMID 28442834

Citations 6

Authors

Cevdet Duran

Baris Sevinc

Orkide Kutlu

Omer Karahan

Affiliations

Soon will be listed here.

Abstract

Primary hyperparathyroidism (PHPT) has been considered a cause of insulin resistance (IR) and impaired glucose metabolism. However, there are conflicting results related with the recovery of insulin resistance in patients with PHPT following curative parathyroidectomy. Our aim is to evaluate the effects of curative parathyroidectomy on IR in patients with PHPT. This is a prospective interventional study. Twenty-one consecutive patients with symptomatic PHPT were included into the study. All patients underwent parathyroidectomy. Fasting serum glucose, calcium, phosphorous, parathormone, plasma insulin, and vitamin D levels were measured both at baseline and 2 months after parathyroidectomy. Insulin resistance was calculated by homeostasis of model assessment-insulin resistance (HOMA-IR). Two months after curative parathyroidectomy, serum levels of calcium ( = 0.001), PTH ( < 0.001), insulin ( = 0.003), and HOMA-IR ( = 0.003) decreased, while phosphorous levels increased ( = 0.001). During this period, no changes were observed at vitamin D and glucose levels. We concluded that curative parathyroidectomy decreases HOMA-IR index in patients with PHPT. Studies with larger population and longer follow-up period are required to confirm our results.

Citing Articles

Association Between Primary Hyperparathyroidism and Secondary Diabetes Mellitus: Findings From a Scoping Review.

Barnett M Cureus. 2023; 15(6):e40743.

PMID: 37350980 PMC: 10284313. DOI: 10.7759/cureus.40743.

Effect of Parathyroidectomy on Metabolic Homeostasis in Primary Hyperparathyroidism.

Frey S, Bourgade R, Le May C, Croyal M, Bigot-Corbel E, Renaud-Moreau N J Clin Med. 2022; 11(5).

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Assessment of insulin resistance in patients with primary hyperparathyroidism before and after Parathyroidectomy.

Nikooei Noghani S, Milani N, Afkhamizadeh M, Kabiri M, Bonakdaran S, Vazifeh-Mostaan L Endocrinol Diabetes Metab. 2021; 4(4):e00294.

PMID: 34505755 PMC: 8502214. DOI: 10.1002/edm2.294.

Diabetes and Bone Involvement in Primary Hyperparathyroidism: Literature Review and Our Personal Experience.

Castellano E, Attanasio R, Boriano A, Borretta V, Tassone F, Borretta G Front Endocrinol (Lausanne). 2021; 12:665984.

PMID: 33953702 PMC: 8092358. DOI: 10.3389/fendo.2021.665984.

Parathyroidectomy slows renal function decline in patients with primary hyperparathyroidism.

Liang C, Yeh H, Lo Y, Chou C, Yen T, Tsai H J Endocrinol Invest. 2020; 44(4):755-763.

PMID: 32729050 DOI: 10.1007/s40618-020-01369-4.

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