Expansion of FasL-Expressing CD5 B Cells in Type 1 Diabetes Patients

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2017 Apr 26

PMID 28439273

Citations 13

Authors

Ankit Saxena

Hideo Yagita

Thomas W Donner

Abdel Rahim A Hamad

Affiliations

Soon will be listed here.

Abstract

Fas ligand drives insulitis in the non-obese diabetic mouse model of type 1 diabetes (T1D) and negatively regulates IL-10-producing (IL-10) CD5 B cells in pancreata. Relevance of these phenomena to the human disease is poorly understood. Here, using splenocytes from T1D, autoantibody (Ab), and non-diabetic (ND) human subjects, we show that a subpopulation of CD5 B cells that is characterized by expression of FasL (FasLCD5) was significantly elevated in T1D subjects, many of whom had significantly reduced frequency of IL-10CD5 B cells compared to Ab subjects. The majority of FasLCD5 B cells did not produce cytokines and were more highly resistant to activation-induced cell death than their IL-10CD5 counterparts. These results associate expansion of FasL-expressing CD5 B cells with T1D and lay the groundwork for future mechanistic studies to understand specific role in disease pathogenesis.

Citing Articles

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