Detailed Transcription Map of Aleutian Mink Disease Parvovirus

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1988 Oct 1

PMID 2843669

Citations 42

Authors

S Alexandersen

M E Bloom

S Perryman

Affiliations

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Abstract

We studied the transcription program of Aleutian mink disease parvovirus (ADV) by using a combination of cDNA cloning and sequencing, primer extension, and Northern (RNA) blot hybridization with splice-specific oligonucleotides. The 4.8-kilobase ADV genome was transcribed in the rightward direction, yielding plus-sense polyadenylated transcripts of 4.3 (R1 RNA), 2.8 (R2), 2.8 (R3), 1.1 (RX), and 0.85 (R2') kilobases. Each RNA transcript had potential translation initiation sites within open reading frames, suggesting protein translation, and a scheme encompassing ADV structural and nonstructural proteins is proposed. Each of the five RNA transcripts had a characteristic set of splices and originated from a promoter at nucleotide 152 (map unit 3 [R1, R2, R2', and RX]) or at nucleotide 1729 (map unit 36 [R3]). The transcripts terminated with a poly(A) tail at one of two positions: either at map unit 53 (R2' and RX) or at map unit 92 (R1, R2, and R3). Similarities with and differences from the transcription maps of other parvoviruses are discussed, and possible roles of the unique features found in ADV transcription are related to the special pathogenic features of this virus.

Citing Articles

Prevalence of Aleutian Mink Disease Virus (AMDV) in Free-Ranging American Mink from Biebrza and Narew National Parks (Poland)-An Epidemiological Concern.

Przywara K, Siemionek J, Jakubowski T, Konczyk-Kmiecik K, Szczerba-Turek A Animals (Basel). 2024; 14(17).

PMID: 39272370 PMC: 11393953. DOI: 10.3390/ani14172584.

Phagocytic Activity, Oxygen Metabolism and Serum Amyloid a Concentration in Peripheral Blood of Mink with Subclinical Aleutian Virus Infection.

Zmuda A, Lisiecka U, Dudek K, Dabrowski R, Gasiorek B, Winiarczyk S Animals (Basel). 2022; 12(8).

PMID: 35454234 PMC: 9030866. DOI: 10.3390/ani12080987.

AMDV Vaccine: Challenges and Perspectives.

Markarian N, Abrahamyan L Viruses. 2021; 13(9).

PMID: 34578415 PMC: 8472842. DOI: 10.3390/v13091833.

Aleutian mink disease virus in free-ranging mink from Sweden.

Persson S, Jensen T, Blomstrom A, Appelberg M, Magnusson U PLoS One. 2015; 10(3):e0122194.

PMID: 25822750 PMC: 4379071. DOI: 10.1371/journal.pone.0122194.

Molecular characterization of the small nonstructural proteins of parvovirus Aleutian mink disease virus (AMDV) during infection.

Huang Q, Luo Y, Cheng F, Best S, Bloom M, Qiu J Virology. 2014; 452-453:23-31.

PMID: 24606679 PMC: 3955004. DOI: 10.1016/j.virol.2014.01.005.

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