Corticotropin-releasing Hormone-binding Protein and Stress: from Invertebrates to Humans

Overview

Journal Stress

Publisher Informa Healthcare

Specialties Biology
Neurology

Date 2017 Apr 25

PMID 28436309

Citations 50

Authors

Kyle D Ketchesin

Gwen S Stinnett

Audrey F Seasholtz

Affiliations

Soon will be listed here.

Abstract

Corticotropin-releasing hormone (CRH) is a key regulator of the stress response. This peptide controls the hypothalamic-pituitary-adrenal (HPA) axis as well as a variety of behavioral and autonomic stress responses via the two CRH receptors, CRH-R1 and CRH-R2. The CRH system also includes an evolutionarily conserved CRH-binding protein (CRH-BP), a secreted glycoprotein that binds CRH with subnanomolar affinity to modulate CRH receptor activity. In this review, we discuss the current literature on CRH-BP and stress across multiple species, from insects to humans. We describe the regulation of CRH-BP in response to stress, as well as genetic mouse models that have been utilized to elucidate the in vivo role(s) of CRH-BP in modulating the stress response. Finally, the role of CRH-BP in the human stress response is examined, including single nucleotide polymorphisms in the human CRHBP gene that are associated with stress-related affective disorders and addiction. Lay summary The stress response is controlled by corticotropin-releasing hormone (CRH), acting via CRH receptors. However, the CRH system also includes a unique CRH-binding protein (CRH-BP) that binds CRH with an affinity greater than the CRH receptors. In this review, we discuss the role of this highly conserved CRH-BP in regulation of the CRH-mediated stress response from invertebrates to humans.

Citing Articles

Innovative Dual mRNA-Lipid Nanoparticle Therapy Targeting CRHBP and CFHR3 for Enhanced Treatment of Hepatocellular Carcinoma.

Fu T, Zhou B, Li Y, Liu W, Xie Y, Mo Z Int J Nanomedicine. 2024; 19:13183-13199.

PMID: 39664759 PMC: 11633302. DOI: 10.2147/IJN.S498065.

CRHBP, a novel multiple cancer biomarker connected with better prognosis and anti-tumorigenicity.

Yoo W, Choi H, Lee J, Lee Y, Park K, Noh K Cancer Cell Int. 2024; 24(1):391.

PMID: 39614295 PMC: 11607943. DOI: 10.1186/s12935-024-03562-4.

Multi-organ transcriptome atlas of a mouse model of relative energy deficiency in sport.

van Rosmalen L, Zhu J, Maier G, Gacasan E, Lin T, Zhemchuzhnikova E Cell Metab. 2024; 36(9):2015-2037.e6.

PMID: 39232281 PMC: 11378950. DOI: 10.1016/j.cmet.2024.08.001.

Stress, hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-gonadal axis, and aggression.

Mbiydzenyuy N, Qulu L Metab Brain Dis. 2024; 39(8):1613-1636.

PMID: 39083184 PMC: 11535056. DOI: 10.1007/s11011-024-01393-w.

CRF binding protein activity in the hypothalamic paraventricular nucleus is essential for stress adaptations and normal maternal behaviour in lactating rats.

Sanson A, Krieg P, Schramm M, Kellner K, Maloumby R, Klampfl S Neurobiol Stress. 2024; 30:100631.

PMID: 38601362 PMC: 11004997. DOI: 10.1016/j.ynstr.2024.100631.

References

McEwen B . Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. Eur J Pharmacol. 2008; 583(2-3):174-85. PMC: 2474765. DOI: 10.1016/j.ejphar.2007.11.071. View

Hsu S, Hsueh A . Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. Nat Med. 2001; 7(5):605-11. DOI: 10.1038/87936. View

McClennen S, Seasholtz A . Transcriptional regulation of corticotropin-releasing hormone-binding protein gene expression in astrocyte cultures. Endocrinology. 1999; 140(9):4095-103. DOI: 10.1210/endo.140.9.6978. View

Kishimoto T, Pearse 2nd R, Lin C, Rosenfeld M . A sauvagine/corticotropin-releasing factor receptor expressed in heart and skeletal muscle. Proc Natl Acad Sci U S A. 1995; 92(4):1108-12. PMC: 42647. DOI: 10.1073/pnas.92.4.1108. View

Davydow D, Kohen R, Hough C, Tracy J, Zatzick D, Katon W . A pilot investigation of the association of genetic polymorphisms regulating corticotrophin-releasing hormone with posttraumatic stress and depressive symptoms in medical-surgical intensive care unit survivors. J Crit Care. 2013; 29(1):101-6. PMC: 3865113. DOI: 10.1016/j.jcrc.2013.08.016. View

Lovejoy D, Chang B, Lovejoy N, del Castillo J . Molecular evolution of GPCRs: CRH/CRH receptors. J Mol Endocrinol. 2014; 52(3):T43-60. DOI: 10.1530/JME-13-0238. View

Westphal N, Seasholtz A . CRH-BP: the regulation and function of a phylogenetically conserved binding protein. Front Biosci. 2005; 11:1878-91. DOI: 10.2741/1931. View

Lombardo K, Herringa R, Balachandran J, Hsu D, Bakshi V, Roseboom P . Effects of acute and repeated restraint stress on corticotropin-releasing hormone binding protein mRNA in rat amygdala and dorsal hippocampus. Neurosci Lett. 2001; 302(2-3):81-4. DOI: 10.1016/s0304-3940(01)01680-9. View

Mulchahey J, Regmi A, Sheriff S, Balasubramaniam A, Kasckow J . Coordinate and divergent regulation of corticotropin-releasing factor (CRF) and CRF-binding protein expression in an immortalized amygdalar neuronal cell line. Endocrinology. 1999; 140(1):251-9. DOI: 10.1210/endo.140.1.6406. View

10.

Stenzel-Poore M, Heldwein K, Stenzel P, Lee S, Vale W . Characterization of the genomic corticotropin-releasing factor (CRF) gene from Xenopus laevis: two members of the CRF family exist in amphibians. Mol Endocrinol. 1992; 6(10):1716-24. DOI: 10.1210/mend.6.10.1448118. View

11.

Sheikh H, Kryski K, Smith H, Hayden E, Singh S . Corticotropin-releasing hormone system polymorphisms are associated with children's cortisol reactivity. Neuroscience. 2012; 229:1-11. DOI: 10.1016/j.neuroscience.2012.10.056. View

12.

Behan D, Linton E, Lowry P . Isolation of the human plasma corticotrophin-releasing factor-binding protein. J Endocrinol. 1989; 122(1):23-31. DOI: 10.1677/joe.0.1220023. View

13.

Lopez-Olmeda J, Blanco-Vives B, Pujante I, Wunderink Y, Mancera J, Sanchez-Vazquez F . Daily rhythms in the hypothalamus-pituitary-interrenal axis and acute stress responses in a teleost flatfish, Solea senegalensis. Chronobiol Int. 2013; 30(4):530-9. DOI: 10.3109/07420528.2012.754448. View

14.

Wunderink Y, Martinez-Rodriguez G, Yufera M, Montero I, Flik G, Mancera J . Food deprivation induces chronic stress and affects thyroid hormone metabolism in Senegalese sole (Solea senegalensis) post-larvae. Comp Biochem Physiol A Mol Integr Physiol. 2012; 162(4):317-22. DOI: 10.1016/j.cbpa.2012.03.023. View

15.

Tartter M, Ray L . A prospective study of stress and alcohol craving in heavy drinkers. Pharmacol Biochem Behav. 2012; 101(4):625-31. DOI: 10.1016/j.pbb.2012.03.007. View

16.

Stinnett G, Westphal N, Seasholtz A . Pituitary CRH-binding protein and stress in female mice. Physiol Behav. 2015; 150:16-23. PMC: 4546865. DOI: 10.1016/j.physbeh.2015.02.050. View

17.

Maciejewski D, Crowe P, DE SOUZA E, Behan D . Regulation of corticotropin-releasing factor-binding protein expression in cultured rat astrocytes. J Pharmacol Exp Ther. 1996; 278(2):455-61. View

18.

Bowman M, Lopata A, Jaffe R, Golos T, WICKINGS J, Smith R . Corticotropin-releasing hormone-binding protein in primates. Am J Primatol. 2001; 53(3):123-30. DOI: 10.1002/1098-2345(200103)53:3<123::AID-AJP3>3.0.CO;2-V. View

19.

Zohar I, Weinstock M . Differential effect of prenatal stress on the expression of corticotrophin-releasing hormone and its receptors in the hypothalamus and amygdala in male and female rats. J Neuroendocrinol. 2011; 23(4):320-8. DOI: 10.1111/j.1365-2826.2011.02117.x. View

20.

Peto C, Arias C, Vale W, Sawchenko P . Ultrastructural localization of the corticotropin-releasing factor-binding protein in rat brain and pituitary. J Comp Neurol. 1999; 413(2):241-54. View