Genetic Factors in Pathogenesis of Diabetes Mellitus After Kidney Transplantation

Overview

Journal Ther Clin Risk Manag

Publisher Dove Medical Press

Date 2017 Apr 25

PMID 28435278

Citations 7

Authors

Maciej Tarnowski

Sylwia Sluczanowska-Glabowska

Andrzej Pawlik

Malgorzata Mazurek-Mochol

Elzbieta Dembowska

Affiliations

Soon will be listed here.

Abstract

Posttransplant diabetes mellitus (PTDM) is one of the major metabolic complications after transplantation of solid organs including the kidney. This type of diabetes mellitus affects allograft survival, cardiovascular complications and overall patient survival. The modifiable risk factors that contribute to PTDM include obesity, some viral infections (eg, hepatitis C virus, cytomegalovirus) and especially immunosuppressive drugs including corticosteroids, tacrolimus, cyclosporine and sirolimus. Currently, predisposing genetic factors have been considered important in PTDM development. The commonly evaluated genetic determinants include genes encoding transcription factors, cytokines, chemokines, adipokines, ionic channels, glucose transporters, cytochrome P450 enzymes and other enzymes metabolizing drugs, drug transporters. Unfortunately, the results of studies are inconclusive and differ between populations. There is a need for large genome-wide association study to identify the genetic risk factors associated with PTDM development.

Citing Articles

Adverse Drug Events after Kidney Transplantation.

Rostaing L, Jouve T, Terrec F, Malvezzi P, Noble J J Pers Med. 2023; 13(12).

PMID: 38138933 PMC: 10744736. DOI: 10.3390/jpm13121706.

Incidence and relative risk factors in posttransplant diabetes mellitus patients: a retrospective cohort study.

Cheng C, Feng Y, Wang H Korean J Transplant. 2022; 34(4):213-237.

PMID: 35770107 PMC: 9186811. DOI: 10.4285/kjt.20.0026.

Association between Genetic Polymorphisms and Risk of Kidney Posttransplant Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Xu S, Jiang Z, Hu N Int J Clin Pract. 2022; 2022:7140024.

PMID: 35685576 PMC: 9159121. DOI: 10.1155/2022/7140024.

Diabetes and Cardiovascular Risk in Renal Transplant Patients.

Rysz J, Franczyk B, Radek M, Cialkowska-Rysz A, Gluba-Brzozka A Int J Mol Sci. 2021; 22(7).

PMID: 33810367 PMC: 8036743. DOI: 10.3390/ijms22073422.

Analysis of the frequency of single nucleotide polymorphisms in cytokine genes in patients with New Onset Diabetes After Transplant.

Jahromi M, Al-Otaibi T, Gheith O, Farouk Othman N, Mahmoud T, Nair P Sci Rep. 2021; 11(1):6014.

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