Investigating Mechanisms of Tendon Damage by Measuring Multi-scale Recovery Following Tensile Loading

Overview

Journal Acta Biomater

Publisher Elsevier

Specialty Biomedical Engineering

Date 2017 Apr 25

PMID 28435080

Citations 25

Authors

Andrea H Lee

Spencer E Szczesny

Michael H Santare

Dawn M Elliott

Affiliations

Soon will be listed here.

Abstract

Statement Of Significance: Tendon pathology is associated with mechanically induced damage. Damage, as defined in engineering, is an irreversible change in microstructure that alters the macroscopic mechanical properties. Although microstructural damage and changes to macroscale mechanics are likely, this link to microstructural change was not yet established. We conducted multiscale mechanical testing to investigate the mechanism of tendon damage by simultaneously quantifying macroscale mechanical and microstructural changes. We showed that non-recoverable sliding between collagen fibrils is a mechanism for tendon damage. Establishing the mechanism of damage at multiple length scales can improve prevention and rehabilitation strategies for tendon pathology.

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