Poly(adenosine Diphosphate-ribose) Polymerase As Therapeutic Target: Lessons Learned from Its Inhibitors

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Apr 22

PMID 28430591

Citations 10

Authors

Anna Maria Cseh

Zsolt Fabian

Balazs Sumegi

Luca Scorrano

Affiliations

Soon will be listed here.

Abstract

Poly(ADP-ribose) polymerases are a family of DNA-dependent nuclear enzymes catalyzing the transfer of ADP-ribose moieties from cellular nicotinamide-adenine-dinucleotide to a variety of target proteins. Although they have been considered as resident nuclear elements of the DNA repair machinery, recent works revealed a more intricate physiologic role of poly(ADP-ribose) polymerases with numerous extranuclear activities. Indeed, poly(ADP-ribose) polymerases participate in fundamental cellular processes like chromatin remodelling, transcription or regulation of the cell-cycle. These new insight into the physiologic roles of poly(ADP-ribose) polymerases widens the range of human pathologies in which pharmacologic inhibition of these enzymes might have a therapeutic potential. Here, we overview our current knowledge on extranuclear functions of poly(ADP-ribose) polymerases with a particular focus on the mitochondrial ones and discuss potential fields of future clinical applications.

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