Na/K Pump and Beyond: Na/K-ATPase As a Modulator of Apoptosis and Autophagy

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2017 Apr 22

PMID 28430151

Citations 42

Authors

Cassiano Felippe Goncalves-de-Albuquerque

Adriana Ribeiro Silva

Camila Ignacio da Silva

Hugo Caire Castro-Faria-Neto

Patricia Burth

Affiliations

Soon will be listed here.

Abstract

Lung cancer is a leading cause of global cancer deaths. Na/K-ATPase has been studied as a target for cancer treatment. Cardiotonic steroids (CS) trigger intracellular signalling upon binding to Na/K-ATPase. Normal lung and tumour cells frequently express different pump isoforms. Thus, Na/K-ATPase is a powerful target for lung cancer treatment. Drugs targeting Na/K-ATPase may induce apoptosis and autophagy in transformed cells. We argue that Na/K-ATPase has a role as a potential target in chemotherapy in lung cancer treatment. We discuss the effects of Na/K-ATPase ligands and molecular pathways inducing deleterious effects on lung cancer cells, especially those leading to apoptosis and autophagy.

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