Understanding the Entanglement: Neutrophil Extracellular Traps (NETs) in Cystic Fibrosis

Overview

Journal Front Cell Infect Microbiol

Specialties Cell Biology
Infectious Diseases
Microbiology

Date 2017 Apr 22

PMID 28428948

Citations 45

Authors

Saira R Martinez-Aleman

Lizbeth Campos-Garcia

Jose P Palma-Nicolas

Romel Hernandez-Bello

Gloria M Gonzalez

Alejandro Sanchez-Gonzalez

Affiliations

Soon will be listed here.

Abstract

Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the gene that codes for the CF trans-membrane conductance regulator. These mutations result in abnormal secretions viscous airways of the lungs, favoring pulmonary infection and inflammation in the middle of neutrophil recruitment. Recently it was described that neutrophils can contribute with disease pathology by extruding large amounts of nuclear material through a mechanism of cell death known as Neutrophil Extracellular Traps (NETs) into the airways of patients with CF. Additionally, NETs production can contribute to airway colonization with bacteria, since they are the microorganisms most frequently found in these patients. In this review, we will discuss the implication of individual or mixed bacterial infections that most often colonize the lung of patients with CF, and the NETs role on the disease.

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