MiR-590-3p Suppresses Epithelial-mesenchymal Transition in Intrahepatic Cholangiocarcinoma by Inhibiting SIP1 Expression

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Apr 21

PMID 28423728

Citations 17

Authors

Chao Zu

Shizhang Liu

Wei Cao

Zongzhi Liu

Hui Qiang

Yong Li

Chong Cheng

Le Ji

Jianhui Li

Jingyuan Li

Affiliations

Soon will be listed here.

Abstract

The functional roles and clinical significances of miR-590-3p in ICC remain unclear. In the current study, we investigated the expression of miR-590-3p in tissues and sera of ICC by real-time quantitative polymerase chain reaction. We found miR-590-3p was significantly down-regulated in the sera and tissues of ICC patients, especially in those patients with lymph node metastasis or distant metastasis. AUC curves and Cox proportional hazards mode revealed serum miR-590-3p could be novel diagnostic and prognostic biomarker for ICC patients. MiR-590-3p dramatically suppressed epithelial-mesenchymal transition, cell migration, and invasion of ICC cells. SIP1 was identified as direct and functional target of miR-590-3p in ICC cells by luciferase assays. Finally, we found SIP1 expression was inversely correlated with miR-590-3p and closely related to diminished survival in ICC patients. These findings reveal functional and mechanistic roles of miR-590-3p and EMT activator SIP1 in the pathogenesis of ICC.

Citing Articles

Functional role and epithelial to mesenchymal transition of the miR-590-3p/MDM2 axis in hepatocellular carcinoma.

Youssef A, Mahmoud Khaled G, Amleh A BMC Cancer. 2023; 23(1):396.

PMID: 37138218 PMC: 10157954. DOI: 10.1186/s12885-023-10861-y.

miR-590-3p protects against ischaemia/reperfusion injury in an oxygen-glucose deprivation and reoxygenation cellular model by regulating HMGB1/TLR4/MyD88/NF-κB signalling.

Wang Y, Jin F, Huang L, Wu W, Hu W, Huang T Histol Histopathol. 2022; 38(8):941-951.

PMID: 36511422 DOI: 10.14670/HH-18-562.

Cancer-associated fibroblasts promote tumor cell growth via miR-493-5p in intrahepatic cholangiocarcinoma.

Toshida K, Itoh S, Harada N, Morinaga A, Yugawa K, Tomiyama T Cancer Sci. 2022; 114(3):937-947.

PMID: 36369960 PMC: 9986089. DOI: 10.1111/cas.15644.

The Role of microRNAs in Cholangiocarcinoma.

Shi T, Morishita A, Kobara H, Masaki T Int J Mol Sci. 2021; 22(14).

PMID: 34299246 PMC: 8306241. DOI: 10.3390/ijms22147627.

Aspirin inhibits cholangiocarcinoma cell proliferation via cell cycle arrest in vitro and in vivo.

Shi T, Gong J, Fujita K, Nishiyama N, Iwama H, Liu S Int J Oncol. 2021; 58(2):199-210.

PMID: 33491760 PMC: 7864011. DOI: 10.3892/ijo.2020.5165.

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