Identification of Long Non-coding RNAs GAS5, Linc0597 and Lnc-DC in Plasma As Novel Biomarkers for Systemic Lupus Erythematosus

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Apr 21

PMID 28423570

Citations 58

Authors

Guo-Cui Wu

Jun Li

Rui-Xue Leng

Xiang-Pei Li

Xiao-Mei Li

De-Guang Wang

Hai-Feng Pan

Dong-Qing Ye

Affiliations

Soon will be listed here.

Abstract

Despite increasing evidence that long non-coding RNAs (lncRNAs) widely take part in human diseases, the role of lncRNAs in systemic lupus erythematosus (SLE) is largely unknown. In this study, we performed a two-stage study to explore the plasma levels of five lncRNAs (GAS5, linc0949, linc0597, HOTAIRM1 and lnc-DC) and their potential as SLE biomarkers. Compared with healthy controls, plasma levels of GAS5 and lnc-DC were significantly decreased (P < 0.001 and P = 0.002, respectively) while linc0597 were overexpressed in SLE patients (P < 0.001). When SLE patients were divided into SLE without nephritis and lupus nephritis (LN), the levels of lnc-DC were significantly higher in LN compared with SLE without nephritis (P = 0.018), but no significant difference in levels of GAS5 and linc0597 were found between LN and SLE without nephritis; plasma linc0949 level showed no significant difference in all comparisons. Further evaluation on potential biomarkers showed that GAS5, linc0597 and lnc-DC may specifically identify patients with SLE, the combination of GAS5 and linc0597 provided better diagnostic accuracy; lnc-DC may discriminate LN from SLE without nephritis. In summary, GAS5, linc0597 and lnc-DC in plasma could be potential biomarkers for SLE.

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