Targeting the Nuclear RNA Exosome: Poly(A) Binding Proteins Enter the Stage

Overview

Journal RNA Biol

Specialty Molecular Biology

Date 2017 Apr 20

PMID 28421898

Citations 20

Authors

Nicola Meola

Torben Heick Jensen

Affiliations

Soon will be listed here.

Abstract

Centrally positioned in nuclear RNA metabolism, the exosome deals with virtually all transcript types. This 3'-5' exo- and endo-nucleolytic degradation machine is guided to its RNA targets by adaptor proteins that enable substrate recognition. Recently, the discovery of the 'Poly(A) tail exosome targeting (PAXT)' connection as an exosome adaptor to human nuclear polyadenylated transcripts has relighted the interest of poly(A) binding proteins (PABPs) in both RNA productive and destructive processes.

Citing Articles

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