Imaging TMS: Antidepressant Mechanisms and Treatment Optimization

Overview

Journal Int Rev Psychiatry

Publisher Informa Healthcare

Specialty Psychiatry

Date 2017 Apr 20

PMID 28420271

Citations 5

Authors

Marc Dubin

Affiliations

Soon will be listed here.

Abstract

With the antidepressant efficacy of Transcranial Magnetic Stimulation well-established by several meta-analyses, there is growing interest in its mechanism of action. TMS has been shown to engage, and in some cases, normalize functional connectivity and neurotransmitter levels within networks dysfunctional in the depressed state. In this review, I will suggest candidate biomarkers, based on neuroimaging, that may be predictive of response to TMS. I will then review the effects of TMS on networks and neurotransmitter systems involved in depression. Throughout, I will also discuss how our current understanding of response predication and network engagement may be used to personalize treatment and optimize its efficacy.

Citing Articles

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Effect of transcranial magnetic stimulation on treatment effect and immune function.

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Maintenance treatment of transcranial magnetic stimulation (TMS) for treatment-resistant depression patients responding to acute TMS treatment.

Chang J, Chu Y, Ren Y, Li C, Wang Y, Chu X Int J Physiol Pathophysiol Pharmacol. 2020; 12(5):128-133.

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Treating refractory depression in Parkinson's disease: a meta-analysis of transcranial magnetic stimulation.

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