CYP3A4 is a Crosslink Between Vitamin D and Calcineurin Inhibitors in Solid Organ Transplant Recipients: Implications for Bone Health

Overview

Journal Pharmacogenomics J

Specialties Genetics
Molecular Biology
Pharmacology

Date 2017 Apr 19

PMID 28418012

Citations 7

Authors

A Prytula

K Cransberg

A Raes

Affiliations

Soon will be listed here.

Abstract

The use of calcineurin inhibitors (CNIs) and vitamin D deficiency may contribute to the pathogenesis of post-transplant bone disease. CNIs and 1,25-dihydroxyvitamin D₃ (1,25(OH)D) are substrates of the drug-metabolizing enzyme CYP3A4. This review summarizes the indications for the use of activated vitamin D analogs in post-transplant care and the current knowledge on the impact of CNIs on bone. We searched for clinical evidence of the interaction between CNIs and 1,25(OH)D. We also provide an overview of the literature on the interplay between vitamin D metabolism and CYP3A4 in experimental and clinical settings and discuss its possible implications for solid organ transplant recipients. In conclusion, there is a body of evidence on the interplay between vitamin D and the drug-metabolizing enzyme CYP3A4, which may have therapeutic implications.

Citing Articles

The Role of Vitamin D Metabolism Genes and Their Genomic Background in Shaping Cyclosporine A Dosage Parameters after Kidney Transplantation.

Kotowska K, Wojciuk B, Sienko J, Bogacz A, Stukan I, Drozdzal S J Clin Med. 2024; 13(16).

PMID: 39201108 PMC: 11355102. DOI: 10.3390/jcm13164966.

Interplay of Vitamin D and CYP3A4 Polymorphisms in Endocrine Disorders and Cancer.

Kasarla S, Garikapati V, Kumar Y, Dodoala S Endocrinol Metab (Seoul). 2022; 37(3):392-407.

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Vitamin D Deficiency, Osteoporosis and Effect on Autoimmune Diseases and Hematopoiesis: A Review.

De Martinis M, Allegra A, Sirufo M, Tonacci A, Pioggia G, Raggiunti M Int J Mol Sci. 2021; 22(16).

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To D or not to D: vitamin D in hematopoietic cell transplantation.

Hong S, Ferraro C, Hamilton B, Majhail N Bone Marrow Transplant. 2020; 55(11):2060-2070.

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Free 25-hydroxyvitamin-D concentrations are lower in children with renal transplant compared with chronic kidney disease.

Preka E, Wan M, Price K, Long D, Aitkenhead H, Shroff R Pediatr Nephrol. 2020; 35(6):1069-1079.

PMID: 31970483 PMC: 7184055. DOI: 10.1007/s00467-020-04472-z.

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