Local Conduction During Acute Myocardial Infarction in Rats: Interplay Between Central Sympathetic Activation and Endothelin

Overview

Journal J Arrhythm

Publisher Wiley

Date 2017 Apr 19

PMID 28416983

Citations 3

Authors

Theofilos M Kolettis

Marianthi Kontonika

Vassilios La Rocca

Antonios P Vlahos

Giannis G Baltogiannis

Zenon S Kyriakides

Affiliations

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Abstract

We investigated the effects of autonomic dysfunction and endothelin on local conduction and arrhythmogenesis during myocardial infarction. We recorded ventricular tachyarrhythmias, monophasic action potentials, and activation sequences in wild-type and ET-deficient rats displaying high endothelin levels. Central sympathetic inputs were examined after clonidine administration. Clonidine mitigated early and delayed arrhythmogenesis in ET-deficient and wild-type rats, respectively. The right ventricular activation delay increased in clonidine-treated ET-deficient rats and slightly decreased in wild-type rats. The left ventricular voltage rise decreased in all groups, whereas the activation delay increased mainly in clonidine-treated ET-deficient rats. Central sympathetic activation and endothelin modulate ischemia-induced arrhythmogenesis. Ischemia alters excitability, whereas endothelin impairs local conduction, an action partly counterbalanced by central sympathetic activity.

Citing Articles

Endothelin System and Ischemia-Induced Ventricular Tachyarrhythmias.

Mouchtouri E, Konstantinou T, Lekkas P, Kolettis T Life (Basel). 2022; 12(10).

PMID: 36295062 PMC: 9605000. DOI: 10.3390/life12101627.

SGLT2 Inhibitors: New Hope for the Treatment of Acute Myocardial Infarction?.

Wu Y, Wang S, Wang L Am J Cardiovasc Drugs. 2022; 22(6):601-613.

PMID: 35947249 DOI: 10.1007/s40256-022-00545-6.

Autonomic function and ventricular tachyarrhythmias during acute myocardial infarction.

Kolettis T World J Exp Med. 2018; 8(1):8-11.

PMID: 30191139 PMC: 6125141. DOI: 10.5493/wjem.v8.i1.8.

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