All the "RAGE" in Lung Disease: The Receptor for Advanced Glycation Endproducts (RAGE) is a Major Mediator of Pulmonary Inflammatory Responses

Overview

Journal Paediatr Respir Rev

Specialties Pediatrics
Pulmonary Medicine

Date 2017 Apr 19

PMID 28416135

Citations 129

Authors

Elizabeth A Oczypok

Timothy N Perkins

Tim D Oury

Affiliations

Soon will be listed here.

Abstract

The receptor for advanced glycation endproducts (RAGE) is a pro-inflammatory pattern recognition receptor (PRR) that has been implicated in the pathogenesis of numerous inflammatory diseases. It was discovered in 1992 on endothelial cells and was named for its ability to bind advanced glycation endproducts and promote vascular inflammation in the vessels of patients with diabetes. Further studies revealed that RAGE is most highly expressed in lung tissue and spurred numerous explorations into RAGE's role in the lung. These studies have found that RAGE is an important mediator in allergic airway inflammation (AAI) and asthma, pulmonary fibrosis, lung cancer, chronic obstructive pulmonary disease (COPD), acute lung injury, pneumonia, cystic fibrosis, and bronchopulmonary dysplasia. RAGE has not yet been targeted in the lungs of paediatric or adult clinical populations, but the development of new ways to inhibit RAGE is setting the stage for the emergence of novel therapeutic agents for patients suffering from these pulmonary conditions.

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