Pluripotent Stem Cells to Hepatocytes, the Journey So Far

Overview

Journal Biomed Rep

Specialty Biochemistry

Date 2017 Apr 18

PMID 28413633

Citations 20

Authors

Anwar A Palakkan

Jyoti Nanda

James A Ross

Affiliations

Soon will be listed here.

Abstract

Over the past several years, there has been substantial progress in the field of regenerative medicine, which has enabled new possibilities for research and clinical application. For example, there are ongoing efforts directed at generating functional hepatocytes from adult-derived pluripotent cells for toxicity screening, generating disease models or, in the longer term, for the treatment of liver failure. In the present review, the authors summarise recent developments in regenerative medicine and pluripotent stem cells, the methods and tissues used for reprogramming and the differentiation of induced pluripotent stem cells (iPSCs) into hepatocyte-like cells. In addition, the hepatic disease models developed using iPSC technologies are discussed, as well as the potential for gene editing.

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