Lewy Body Disorders

Overview

Journal Neurol Clin

Specialty Neurology

Date 2017 Apr 16

PMID 28410662

Citations 23

Authors

Douglas Galasko

Affiliations

Soon will be listed here.

Abstract

Dementia syndromes associated with Lewy bodies are subdivided into dementia with Lewy bodies (DLB), an underdiagnosed cause of dementia in the elderly, and Parkinson disease with dementia (PDD), cognitive impairment appearing in people diagnosed with Parkinson disease. Their neuropathologic substrates are the widespread distribution of aggregates of the protein α-synuclein in neurons in cortical brain regions, accompanied by variable Alzheimer pathology. Clinical features of DLB and PDD include distinctive changes in cognition, behavior, movement, sleep, and autonomic function. Diagnostic criteria for DLB and PDD incorporate these features. Current treatment options for DLB and PDD are symptomatic.

Citing Articles

Joint analysis of proteome, transcriptome, and multi-trait analysis to identify novel Parkinson's disease risk genes.

Shi J, Mao C, Guo Y, Fan Y, Hao X, Li S Aging (Albany NY). 2024; 16(2):1555-1580.

PMID: 38240717 PMC: 10866412. DOI: 10.18632/aging.205444.

Dopamine levels determined in synthetic urine using an electrochemical tyrosinase biosensor based on ZnO@Au core-shell.

Beatto T, Gomes W, Etchegaray A, Gupta R, Mendes R RSC Adv. 2023; 13(47):33424-33429.

PMID: 38025875 PMC: 10644153. DOI: 10.1039/d3ra06277e.

Gray matter loss relates to dual task gait in Lewy body disorders and aging.

Subotic A, Gee M, Nelles K, Ba F, Dadar M, Duchesne S J Neurol. 2023; 271(2):962-975.

PMID: 37902878 DOI: 10.1007/s00415-023-12052-y.

Efficacy of Adjunctive Therapy with Zonisamide Versus Increased Dose of Levodopa for Motor Symptoms in Patients with Dementia with Lewy Bodies: The Randomized, Controlled, Non-Inferiority DUEL Study.

Ikeda M, Mori E, Orimo S, Yamada T, Konishi O J Alzheimers Dis. 2023; 95(1):251-264.

PMID: 37483001 PMC: 10578290. DOI: 10.3233/JAD-230335.

Dual-task gait and white matter hyperintensities in Lewy body diseases: An exploratory analysis.

Fatokun I, Gee M, Nelles K, Ba F, Dadar M, Duchesne S Front Aging Neurosci. 2023; 15:1088050.

PMID: 37091522 PMC: 10113527. DOI: 10.3389/fnagi.2023.1088050.

References

Bomasang-Layno E, Fadlon I, Murray A, Himelhoch S . Antidepressive treatments for Parkinson's disease: A systematic review and meta-analysis. Parkinsonism Relat Disord. 2015; 21(8):833-42. DOI: 10.1016/j.parkreldis.2015.04.018. View

Nedelska Z, Ferman T, Boeve B, Przybelski S, Lesnick T, Murray M . Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies. Neurobiol Aging. 2014; 36(1):452-61. PMC: 4268128. DOI: 10.1016/j.neurobiolaging.2014.07.005. View

Boot B, Orr C, Ahlskog J, Ferman T, Roberts R, Pankratz V . Risk factors for dementia with Lewy bodies: a case-control study. Neurology. 2013; 81(9):833-40. PMC: 3908463. DOI: 10.1212/WNL.0b013e3182a2cbd1. View

Onofrj M, Varanese S, Bonanni L, Taylor J, Antonini A, Valente E . Cohort study of prevalence and phenomenology of tremor in dementia with Lewy bodies. J Neurol. 2013; 260(7):1731-42. PMC: 3705145. DOI: 10.1007/s00415-013-6853-y. View

Walker M, Ayre G, Cummings J, Wesnes K, McKeith I, OBrien J . The Clinician Assessment of Fluctuation and the One Day Fluctuation Assessment Scale. Two methods to assess fluctuating confusion in dementia. Br J Psychiatry. 2000; 177:252-6. DOI: 10.1192/bjp.177.3.252. View

Boeve B, Silber M, Ferman T . REM sleep behavior disorder in Parkinson's disease and dementia with Lewy bodies. J Geriatr Psychiatry Neurol. 2004; 17(3):146-57. DOI: 10.1177/0891988704267465. View

Tsuang D, Leverenz J, Lopez O, Hamilton R, Bennett D, Schneider J . APOE ε4 increases risk for dementia in pure synucleinopathies. JAMA Neurol. 2013; 70(2):223-8. PMC: 3580799. DOI: 10.1001/jamaneurol.2013.600. View

Bras J, Guerreiro R, Darwent L, Parkkinen L, Ansorge O, Escott-Price V . Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies. Hum Mol Genet. 2014; 23(23):6139-46. PMC: 4222357. DOI: 10.1093/hmg/ddu334. View

Schneider L, Dagerman K, Insel P . Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized, placebo-controlled trials. Am J Geriatr Psychiatry. 2006; 14(3):191-210. DOI: 10.1097/01.JGP.0000200589.01396.6d. View

10.

Emre M . Dementia associated with Parkinson's disease. Lancet Neurol. 2003; 2(4):229-37. DOI: 10.1016/s1474-4422(03)00351-x. View

11.

Matsunaga S, Kishi T, Iwata N . Memantine for Lewy body disorders: systematic review and meta-analysis. Am J Geriatr Psychiatry. 2014; 23(4):373-383. DOI: 10.1016/j.jagp.2013.11.007. View

12.

Gomperts S, Locascio J, Makaretz S, Schultz A, Caso C, Vasdev N . Tau Positron Emission Tomographic Imaging in the Lewy Body Diseases. JAMA Neurol. 2016; 73(11):1334-1341. PMC: 5287290. DOI: 10.1001/jamaneurol.2016.3338. View

13.

Minoshima S, Foster N, Sima A, Frey K, Albin R, Kuhl D . Alzheimer's disease versus dementia with Lewy bodies: cerebral metabolic distinction with autopsy confirmation. Ann Neurol. 2001; 50(3):358-65. DOI: 10.1002/ana.1133. View

14.

Hely M, Reid W, Adena M, Halliday G, Morris J . The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years. Mov Disord. 2008; 23(6):837-44. DOI: 10.1002/mds.21956. View

15.

Toledo J, Gopal P, Raible K, Irwin D, Brettschneider J, Sedor S . Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology. Acta Neuropathol. 2016; 131(3):393-409. PMC: 4754135. DOI: 10.1007/s00401-015-1526-9. View

16.

Stubendorff K, Larsson V, Ballard C, Minthon L, Aarsland D, Londos E . Treatment effect of memantine on survival in dementia with Lewy bodies and Parkinson's disease with dementia: a prospective study. BMJ Open. 2014; 4(7):e005158. PMC: 4091277. DOI: 10.1136/bmjopen-2014-005158. View

17.

Vann Jones S, OBrien J . The prevalence and incidence of dementia with Lewy bodies: a systematic review of population and clinical studies. Psychol Med. 2013; 44(4):673-83. DOI: 10.1017/S0033291713000494. View

18.

Delgado-Alvarado M, Gago B, Navalpotro-Gomez I, Jimenez-Urbieta H, Rodriguez-Oroz M . Biomarkers for dementia and mild cognitive impairment in Parkinson's disease. Mov Disord. 2016; 31(6):861-81. DOI: 10.1002/mds.26662. View

19.

Tiraboschi P, Corso A, Guerra U, Nobili F, Piccardo A, Calcagni M . (123) I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography and (123) I-metaiodobenzylguanidine myocardial scintigraphy in differentiating dementia with lewy bodies from other dementias: A.... Ann Neurol. 2016; 80(3):368-78. DOI: 10.1002/ana.24717. View

20.

Collerton D, Burn D, McKeith I, OBrien J . Systematic review and meta-analysis show that dementia with Lewy bodies is a visual-perceptual and attentional-executive dementia. Dement Geriatr Cogn Disord. 2003; 16(4):229-37. DOI: 10.1159/000072807. View