CSH Guidelines for the Diagnosis and Treatment of Drug-induced Liver Injury

Overview

Journal Hepatol Int

Publisher Springer

Specialty Gastroenterology

Date 2017 Apr 14

PMID 28405790

Citations 116

Authors

Yue-Cheng Yu

Yi-Min Mao

Cheng-Wei Chen

Jin-Jun Chen

Jun Chen

Wen-Ming Cong

Yang Ding

Zhong-Ping Duan

Qing-Chun Fu

Xiao-Yan Guo

Peng Hu

Xi-Qi Hu

Ji-Dong Jia

Rong-Tao Lai

Dong-Liang Li

Ying-Xia Liu

Lun-Gen Lu

Shi-Wu Ma

Xiong Ma

Yue-Min Nan

Hong Ren

Tao Shen

Hao Wang

Ji-Yao Wang

Tai-Ling Wang

Xiao-Jin Wang

Lai Wei

Qing Xie

Wen Xie

Chang-Qing Yang

Dong-Liang Yang

Yan-Yan Yu

Min-de Zeng

Li Zhang

Xin-Yan Zhao

Hui Zhuang

Affiliations

Soon will be listed here.

Abstract

Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. It can be induced by small chemical molecules, biological agents, traditional Chinese medicines (TCM), natural medicines (NM), health products (HP), and dietary supplements (DS). Idiosyncratic DILI is far more common than intrinsic DILI clinically and can be classified into hepatocellular injury, cholestatic injury, hepatocellular-cholestatic mixed injury, and vascular injury based on the types of injured target cells. The CSH guidelines summarized the epidemiology, pathogenesis, pathology, and clinical manifestation and gives 16 evidence-based recommendations on diagnosis, differential diagnosis, treatment, and prevention of DILI.

Citing Articles

Drug-Induced Liver Injury-Pharmacological Spectrum Among Children.

Maris B, Grama A, Pop T Int J Mol Sci. 2025; 26(5).

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Clinical features and prognosis of drug-induced liver injury in patients with non-alcoholic fatty liver.

Zhao Y, Li J, Liu Y, Zhu Y, Zhang Y, Zheng W World J Hepatol. 2025; 17(2):101741.

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Persistent hepatocyte secretory failure in lopinavir/ritonavir related to drug-induced liver injury: a case report.

Sun Y, Wang R, Wang C, Shao X, Zheng X, Li H Front Med (Lausanne). 2025; 12:1492002.

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Risk Prediction of Liver Injury in Pediatric Tuberculosis Treatment: Development of an Automated Machine Learning Model.

Zeng Y, Lu H, Li S, Shi Q, Liu L, Gong Y Drug Des Devel Ther. 2025; 19():239-250.

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Novel Optical Criteria and Mechanisms of Critical Decline in Liver Regenerative Potential.

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