Family History is an Independent Risk Factor for the Progression of Gastric Atrophy Among Patients with Infection

Overview

Journal United European Gastroenterol J

Publisher Wiley

Specialty Gastroenterology

Date 2017 Apr 14

PMID 28405319

Citations 13

Authors

Toshihiro Nishizawa

Hidekazu Suzuki

Kosuke Sakitani

Hiroharu Yamashita

Shuntaro Yoshida

Keisuke Hata

Takamitsu Kanazawa

Naoto Fujiwara

Takanori Kanai

Naohisa Yahagi

Osamu Toyoshima

Affiliations

Soon will be listed here.

Abstract

Background And Aim: Risk factors for progression of gastric atrophy have not been fully elucidated. The aim of this study was to evaluate the risk factors for the development of atrophic gastritis in patients with ( ) infection.

Methods: We reviewed 206 -infected patients retrospectively. Endoscopic gastric atrophy was classified into closed- and open-type. We conducted univariate and multivariate logistic regression analyses on the contribution of age, sex, body mass index, past history of cancer, the first-degree family history of gastric cancer, habitual smoking and alcohol drinking, and endoscopic findings of gastric ulcer or duodenal ulcer for open-type gastric atrophy.

Results: On multivariate analysis, age (odds ratio = 1.079, 95% confidence interval = 1.048-1.11, < 0.001), family history of gastric cancer (odds ratio = 3.967, 95% confidence interval = 1.414-10.6, = 0.006) and duodenal ulcer (odds ratio = 0.834, 95% confidence interval = 0.711-0.977, = 0.024) were the factors independently associated with open-type gastric atrophy.

Conclusions: A first-degree family history of gastric cancer, absence of duodenal ulcer, and old age were independent risk factors for the progression of gastric atrophy among -infected patients. Careful examination with upper gastrointestinal endoscopy is necessary in patients with such risk factors.

Citing Articles

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The simplified Kyoto classification score is consistent with the ABC method of classification as a grading system for endoscopic gastritis.

Nishizawa T, Toyoshima O, Kondo R, Sekiba K, Tsuji Y, Ebinuma H J Clin Biochem Nutr. 2021; 68(1):101-104.

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A single nucleotide polymorphism in is associated with endoscopic grading in Kyoto classification of gastritis.

Toyoshima O, Nishizawa T, Sekiba K, Matsuno T, Kondo R, Watanabe H J Clin Biochem Nutr. 2021; 68(1):73-77.

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Endoscopy-based Kyoto classification score of gastritis related to pathological topography of neutrophil activity.

Toyoshima O, Nishizawa T, Yoshida S, Sakaguchi Y, Nakai Y, Watanabe H World J Gastroenterol. 2020; 26(34):5146-5155.

PMID: 32982115 PMC: 7495031. DOI: 10.3748/wjg.v26.i34.5146.

Nodularity-like appearance in the cardia: novel endoscopic findings for infection.

Toyoshima O, Nishizawa T, Sakitani K, Yamakawa T, Watanabe H, Yoshida S Endosc Int Open. 2020; 8(6):E770-E774.

PMID: 32490162 PMC: 7247899. DOI: 10.1055/a-1136-9890.

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