Kidney Disease and HIV Infection

Overview

Journal Top Antivir Med

Specialties Infectious Diseases
Microbiology

Date 2017 Apr 14

PMID 28402929

Citations 43

Authors

Christina M Wyatt

Affiliations

Soon will be listed here.

Abstract

The risk of acute and chronic kidney disease remains higher in HIV-infected persons than in the general population, and kidney disease in HIV-infected persons is associated with poor outcomes, including increased mortality. HIV-associated nephropathy occurs less frequently in the era of antiretroviral therapy. HIV immune complex kidney disease is being diagnosed more frequently, but the term is currently used to refer to a heterogeneous group of kidney diseases. Comorbid chronic kidney disease poses a growing burden in HIV-infected persons due to an overrepresentation of risk factors such as black race, diabetes, hypertension, and coinfection with hepatitis C virus. Drug-induced kidney toxicity also remains a concern. This article summarizes a presentation by Christina M. Wyatt, MD, at the Ryan White HIV/AIDS Program Clinical Care Conference held in New Orleans, Louisiana, in December 2015.

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References

Inker L, Wyatt C, Creamer R, Hellinger J, Hotta M, Leppo M . Performance of creatinine and cystatin C GFR estimating equations in an HIV-positive population on antiretrovirals. J Acquir Immune Defic Syndr. 2012; 61(3):302-9. PMC: 3598619. DOI: 10.1097/QAI.0b013e31826a6c4f. View

Mills A, Arribas J, Andrade-Villanueva J, DiPerri G, van Lunzen J, Koenig E . Switching from tenofovir disoproxil fumarate to tenofovir alafenamide in antiretroviral regimens for virologically suppressed adults with HIV-1 infection: a randomised, active-controlled, multicentre, open-label, phase 3, non-inferiority study. Lancet Infect Dis. 2015; 16(1):43-52. DOI: 10.1016/S1473-3099(15)00348-5. View

Nadkarni G, Patel A, Yacoub R, Benjo A, Konstantinidis I, Annapureddy N . The burden of dialysis-requiring acute kidney injury among hospitalized adults with HIV infection: a nationwide inpatient sample analysis. AIDS. 2015; 29(9):1061-6. PMC: 4489559. DOI: 10.1097/QAD.0000000000000653. View

Gagneux-Brunon A, Delanaye P, Maillard N, Fresard A, Basset T, Alamartine E . Performance of creatinine and cystatin C-based glomerular filtration rate estimating equations in a European HIV-positive cohort. AIDS. 2013; 27(10):1573-81. DOI: 10.1097/QAD.0b013e32835fac30. View

Muller E, Barday Z, Mendelson M, Kahn D . HIV-positive-to-HIV-positive kidney transplantation--results at 3 to 5 years. N Engl J Med. 2015; 372(7):613-20. PMC: 5090019. DOI: 10.1056/NEJMoa1408896. View

Cooper R, Wiebe N, Smith N, Keiser P, Naicker S, Tonelli M . Systematic review and meta-analysis: renal safety of tenofovir disoproxil fumarate in HIV-infected patients. Clin Infect Dis. 2010; 51(5):496-505. DOI: 10.1086/655681. View

Li Y, Shlipak M, Grunfeld C, Choi A . Incidence and risk factors for acute kidney injury in HIV Infection. Am J Nephrol. 2012; 35(4):327-34. PMC: 3362304. DOI: 10.1159/000337151. View

Mocroft A, Neuhaus J, Peters L, Ryom L, Bickel M, Grint D . Hepatitis B and C co-infection are independent predictors of progressive kidney disease in HIV-positive, antiretroviral-treated adults. PLoS One. 2012; 7(7):e40245. PMC: 3401192. DOI: 10.1371/journal.pone.0040245. View

Wyatt C, Malvestutto C, Coca S, Klotman P, Parikh C . The impact of hepatitis C virus coinfection on HIV-related kidney disease: a systematic review and meta-analysis. AIDS. 2008; 22(14):1799-807. PMC: 2733170. DOI: 10.1097/QAD.0b013e32830e0152. View

10.

Medapalli R, Parikh C, Gordon K, Brown S, Butt A, Gibert C . Comorbid diabetes and the risk of progressive chronic kidney disease in HIV-infected adults: data from the Veterans Aging Cohort Study. J Acquir Immune Defic Syndr. 2012; 60(4):393-9. PMC: 3392432. DOI: 10.1097/QAI.0b013e31825b70d9. View

11.

Sax P, Wohl D, Yin M, Post F, DeJesus E, Saag M . Tenofovir alafenamide versus tenofovir disoproxil fumarate, coformulated with elvitegravir, cobicistat, and emtricitabine, for initial treatment of HIV-1 infection: two randomised, double-blind, phase 3, non-inferiority trials. Lancet. 2015; 385(9987):2606-15. DOI: 10.1016/S0140-6736(15)60616-X. View

12.

Bhasin B, Lau B, Atta M, Fine D, Estrella M, Schwartz G . HIV viremia and T-cell activation differentially affect the performance of glomerular filtration rate equations based on creatinine and cystatin C. PLoS One. 2013; 8(12):e82028. PMC: 3871673. DOI: 10.1371/journal.pone.0082028. View

13.

Lucas G, Ross M, Stock P, Shlipak M, Wyatt C, Gupta S . Clinical practice guideline for the management of chronic kidney disease in patients infected with HIV: 2014 update by the HIV Medicine Association of the Infectious Diseases Society of America. Clin Infect Dis. 2014; 59(9):e96-138. PMC: 4271038. DOI: 10.1093/cid/ciu617. View

14.

Peters L, Grint D, Lundgren J, Rockstroh J, Soriano V, Reiss P . Hepatitis C virus viremia increases the incidence of chronic kidney disease in HIV-infected patients. AIDS. 2012; 26(15):1917-26. DOI: 10.1097/QAD.0b013e3283574e71. View

15.

Mugwanya K, Wyatt C, Celum C, Donnell D, Mugo N, Tappero J . Changes in glomerular kidney function among HIV-1-uninfected men and women receiving emtricitabine-tenofovir disoproxil fumarate preexposure prophylaxis: a randomized clinical trial. JAMA Intern Med. 2014; 175(2):246-54. PMC: 4354899. DOI: 10.1001/jamainternmed.2014.6786. View

16.

Wohl D, Oka S, Clumeck N, Clarke A, Brinson C, Stephens J . Brief Report: A Randomized, Double-Blind Comparison of Tenofovir Alafenamide Versus Tenofovir Disoproxil Fumarate, Each Coformulated With Elvitegravir, Cobicistat, and Emtricitabine for Initial HIV-1 Treatment: Week 96 Results. J Acquir Immune Defic Syndr. 2016; 72(1):58-64. DOI: 10.1097/QAI.0000000000000940. View

17.

Franceschini N, Napravnik S, Eron Jr J, Szczech L, Finn W . Incidence and etiology of acute renal failure among ambulatory HIV-infected patients. Kidney Int. 2005; 67(4):1526-31. DOI: 10.1111/j.1523-1755.2005.00232.x. View

18.

Scherzer R, Estrella M, Li Y, Choi A, Deeks S, Grunfeld C . Association of tenofovir exposure with kidney disease risk in HIV infection. AIDS. 2012; 26(7):867-75. PMC: 3736566. DOI: 10.1097/QAD.0b013e328351f68f. View

19.

Pozniak A, Arribas J, Gathe J, Gupta S, Post F, Bloch M . Switching to Tenofovir Alafenamide, Coformulated With Elvitegravir, Cobicistat, and Emtricitabine, in HIV-Infected Patients With Renal Impairment: 48-Week Results From a Single-Arm, Multicenter, Open-Label Phase 3 Study. J Acquir Immune Defic Syndr. 2015; 71(5):530-7. PMC: 4804743. DOI: 10.1097/QAI.0000000000000908. View

20.

Mocroft A, Kirk O, Reiss P, De Wit S, Sedlacek D, Beniowski M . Estimated glomerular filtration rate, chronic kidney disease and antiretroviral drug use in HIV-positive patients. AIDS. 2010; 24(11):1667-78. DOI: 10.1097/QAD.0b013e328339fe53. View