Engineering and Expressing Circular RNAs Via TRNA Splicing

Overview

Journal RNA Biol

Specialty Molecular Biology

Date 2017 Apr 13

PMID 28402213

Citations 58

Authors

John J Noto

Casey A Schmidt

A Gregory Matera

Affiliations

Soon will be listed here.

Abstract

Circular (circ)RNAs have recently become a subject of great biologic interest. It is now clear that they represent a diverse and abundant class of RNAs with regulated expression and evolutionarily conserved functions. There are several mechanisms by which RNA circularization can occur in vivo. Here, we focus on the biogenesis of tRNA intronic circular RNAs (tricRNAs) in archaea and animals, and we detail their use as research tools for orthogonal, directed circRNA expression in vivo.

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