Lignin-graft-Polyoxazoline Conjugated Triazole a Novel Anti-Infective Ointment to Control Persistent Inflammation

Overview

Journal Sci Rep

Specialty Science

Date 2017 Apr 13

PMID 28401944

Citations 16

Authors

Denial Mahata

Malabendu Jana

Arundhuti Jana

Abhishek Mukherjee

Nibendu Mondal

Tilak Saha

Subhajit Sen

Golok B Nando

Chinmay K Mukhopadhyay

Ranadhir Chakraborty

Santi M Mandal

Affiliations

Soon will be listed here.

Abstract

Lignin, one of the most abundant renewable feedstock, is used to develop a biocompatible hydrogel as anti-infective ointment. A hydrophilic polyoxazoline chain is grafted through ring opening polymerization, possess homogeneous spherical nanoparticles of 10-15 nm. The copolymer was covalently modified with triazole moiety to fortify the antimicrobial and antibiofilm activities. The hydrogel was capable of down regulating the expression level of IL-1β in LPS induced macrophage cells, and to cause significant reduction of iNOS production. It supported cellular anti-inflammatory activity which was confirmed with luciferase assay, western blot, and NF-κB analysis. This novel lignin-based hydrogel tested in-vivo has shown the abilities to prevent infection of burn wound, aid healing, and an anti-inflammatory dressing material. The hydrogel reported here provides a new material platform to introduce a cost-effective and efficient ointment option after undertaking further work to look at its use in the area of clinical practice.

Citing Articles

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Mahata D, Jana M, Mondal S, Manna S, Jana A, Chakraborty A RSC Med Chem. 2025; .

PMID: 39935521 PMC: 11808565. DOI: 10.1039/d4md00878b.

Lignin Isolated by Microwave-Assisted Acid-Catalyzed Solvolysis Induced Cell Death in Mammalian Tumor Cells by Modulating Apoptotic Pathways.

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Fermented Polyherbal Formulation Ameliorates the Severity of Acute Multiple Antibiotics-Resistant -Infected Burn Wound in a Rat Burn Model.

Chakraborty S, Sen S, Das A, Chakraborty R J Pathog. 2024; 2024:3601954.

PMID: 38783899 PMC: 11115993. DOI: 10.1155/2024/3601954.

Navigating Antibacterial Frontiers: A Panoramic Exploration of Antibacterial Landscapes, Resistance Mechanisms, and Emerging Therapeutic Strategies.

Ralhan K, Iyer K, Diaz L, Bird R, Maind A, Zhou Q ACS Infect Dis. 2024; 10(5):1483-1519.

PMID: 38691668 PMC: 11091902. DOI: 10.1021/acsinfecdis.4c00115.

Lignin-Based Hydrogels for the Delivery of Bioactive Chaga Mushroom Extract.

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