Is N-acetylcysteine Infusion an Effective Treatment Option in L-asparaginase Associated Hepatotoxicity?

Overview

Journal Blood Res

Publisher Springer Nature

Specialty Hematology

Date 2017 Apr 13

PMID 28401107

Citations 2

Authors

Zeynep Canan Ozdemir

Ayse Bozkurt Turhan

Makbule Eren

Ozcan Bor

Affiliations

Soon will be listed here.

Citing Articles

TY-S01 protects against alcoholic liver injury in mice by regulating intestinal barrier function and gut microbiota.

Shu X, Wang J, Zhao L, Wang J, Wang P, Zhang F Heliyon. 2023; 9(7):e17878.

PMID: 37539263 PMC: 10395298. DOI: 10.1016/j.heliyon.2023.e17878.

Levocarnitine for asparaginase-induced hepatic injury: a multi-institutional case series and review of the literature.

Schulte R, Madiwale M, Flower A, Hochberg J, Burke M, McNeer J Leuk Lymphoma. 2018; 59(10):2360-2368.

PMID: 29431566 PMC: 10183102. DOI: 10.1080/10428194.2018.1435873.

References

Baumgardner J, Shankar K, Hennings L, Albano E, Badger T, Ronis M . N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis. J Nutr. 2008; 138(10):1872-9. PMC: 2935161. DOI: 10.1093/jn/138.10.1872. View

Jaeschke H, Gores G, Cederbaum A, Hinson J, Pessayre D, Lemasters J . Mechanisms of hepatotoxicity. Toxicol Sci. 2002; 65(2):166-76. DOI: 10.1093/toxsci/65.2.166. View

Alshiekh-Nasany R, Douer D . L-Carnitine for Treatment of Pegasparaginase-Induced Hepatotoxicity. Acta Haematol. 2016; 135(4):208-10. DOI: 10.1159/000442342. View

Al-Nawakil C, Willems L, Mauprivez C, Laffy B, Benmrad M, Tamburini J . Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors. Leuk Lymphoma. 2013; 55(7):1670-4. DOI: 10.3109/10428194.2013.845886. View

Clavell L, Gelber R, Cohen H, Cassady J, Tarbell N, Blattner S . Four-agent induction and intensive asparaginase therapy for treatment of childhood acute lymphoblastic leukemia. N Engl J Med. 1986; 315(11):657-63. DOI: 10.1056/NEJM198609113151101. View

Samuhasaneeto S, Thong-Ngam D, Kulaputana O, Patumraj S, Klaikeaw N . Effects of N-acetylcysteine on oxidative stress in rats with non-alcoholic steatohepatitis. J Med Assoc Thai. 2007; 90(4):788-97. View

Tsuji F, Miyake Y, Aono H, Kawashima Y, Mita S . Effects of bucillamine and N-acetyl-L-cysteine on cytokine production and collagen-induced arthritis (CIA). Clin Exp Immunol. 1999; 115(1):26-31. PMC: 1905176. DOI: 10.1046/j.1365-2249.1999.00749.x. View

Pratt C, Johnson W . Duration and severity of fatty metamorphosis of the liver following L-asparaginase therapy. Cancer. 1971; 28(2):361-4. DOI: 10.1002/1097-0142(197108)28:2<361::aid-cncr2820280215>3.0.co;2-3. View

Kaya I, Citil M, Sozmen M, Karapehlivan M, Cigsar G . Investigation of protective effect of L-carnitine on L-asparaginase-induced acute pancreatic injury in male Balb/c mice. Dig Dis Sci. 2014; 60(5):1290-6. DOI: 10.1007/s10620-014-3461-3. View

10.

Roesmann A, Afify M, Panse J, Eisert A, Steitz J, Tolba R . L-carnitine ameliorates L-asparaginase-induced acute liver toxicity in steatotic rat livers. Chemotherapy. 2013; 59(3):167-75. DOI: 10.1159/000353402. View

11.

Durden D, Salazar A, Distasio J . Kinetic analysis of hepatotoxicity associated with antineoplastic asparaginases. Cancer Res. 1983; 43(4):1602-5. View

12.

Mari M, Morales A, Colell A, Garcia-Ruiz C, Kaplowitz N, Fernandez-Checa J . Mitochondrial glutathione: features, regulation and role in disease. Biochim Biophys Acta. 2012; 1830(5):3317-28. PMC: 3578987. DOI: 10.1016/j.bbagen.2012.10.018. View

13.

Firpi R, Nelson D . Viral hepatitis: manifestations and management strategy. Hematology Am Soc Hematol Educ Program. 2006; :375-80. DOI: 10.1182/asheducation-2006.1.375. View