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Predictive Prognostic Value of Neutrophil-lymphocytes Ratio in Acute Coronary Syndrome

Overview
Journal Indian Heart J
Publisher Elsevier
Date 2017 Apr 13
PMID 28400038
Citations 11
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Abstract

Objective: To assess the relationship between neutrophil-lymphocytes ratio (NLR) at admission and patient outcome over a period of six month in subjects with acute coronary syndrome (ACS).

Methods: A total of 435 consecutive patients presenting with ACS were enrolled and 400 patients completed the study. Patients were categorized into 2 groups: the NLR group 1 (NLR≤5.25; n=265, 66.25%) and the NLR group 2 (NLR>5.25; n=135, 33.75%). The primary outcomes were in-hospital and 6 months mortality.

Results: Forty-seven (11.8%) patients died during 6 months follow up. Higher mortality was seen in NLR group 2 (42/135, 34.1%) compared to NLR group 1 (5/265, 1.9%) with p value <0.001.

Conclusion: Our study suggest that elevated NLR (>5.25) is independently associated with higher all-cause mortality rate up to 6 months period irrespective of ACS type.

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References
1.
Hayasaki T, Kaikita K, Okuma T, Yamamoto E, Kuziel W, Ogawa H . CC chemokine receptor-2 deficiency attenuates oxidative stress and infarct size caused by myocardial ischemia-reperfusion in mice. Circ J. 2006; 70(3):342-51. DOI: 10.1253/circj.70.342. View

2.
Boyle J . Association of coronary plaque rupture and atherosclerotic inflammation. J Pathol. 1997; 181(1):93-9. DOI: 10.1002/(SICI)1096-9896(199701)181:1<93::AID-PATH696>3.0.CO;2-H. View

3.
Cannon C, McCabe C, Wilcox R, Bentley J, Braunwald E . Association of white blood cell count with increased mortality in acute myocardial infarction and unstable angina pectoris. OPUS-TIMI 16 Investigators. Am J Cardiol. 2001; 87(5):636-9, A10. DOI: 10.1016/s0002-9149(00)01444-2. View

4.
Zhao G, Wang S, Wang Z, Sun A, Yang X, Qiu Z . CXCR6 deficiency ameliorated myocardial ischemia/reperfusion injury by inhibiting infiltration of monocytes and IFN-γ-dependent autophagy. Int J Cardiol. 2012; 168(2):853-62. DOI: 10.1016/j.ijcard.2012.10.022. View

5.
Horne B, Anderson J, John J, Weaver A, Bair T, Jensen K . Which white blood cell subtypes predict increased cardiovascular risk?. J Am Coll Cardiol. 2005; 45(10):1638-43. DOI: 10.1016/j.jacc.2005.02.054. View